PRACTICAL ASPECTS OF MILK COLLECTION IN THE RAT
PRACTICAL ASPECTS OF MILK COLLECTION IN THE RAT
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DOI：
10.1258/002367795780739980
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发表时间：
1995-10-01
影响因子：
2.4
通讯作者：
RODGERS, CT
中科院分区：
文献类型：
--
作者：
RODGERS, CT
对于拟用于孕妇或有幼儿的妇女的新型化合物，作为其安全性评估的一部分，需要测定该化合物或其代谢物在哺乳期从母鼠转移到幼崽的可能性。从大鼠挤奶研究中获得的数据也用于支持大鼠围产期和产后研究。因此，有必要从哺乳期大鼠收集多个乳汁样本。在本文中，决定集中关注三个方面：1. 在大鼠挤奶技术开发过程中必须考虑的因素；2. 大鼠挤奶研究的基本研究设计概要；3. 大鼠挤奶技术。
It is a requirement as part of the safety evaluation of novel compounds, which are intended to be administered to pregnant women or women with young children, that the potential for the compound or its metabolites to be transferred from a dam to its litter during lactation is measured. The data obtained from the rat milking studies are also used to support the rat peri- and post-natal studies. Therefore it is necessary to collect multiple milk samples from lactating rats. In this paper it was decided to concentrate on three areas: 1. The factors which had to be considered during the development of the rat milking technique; 2. The outline of the basic study design for a rat milking study; 3. The technique for milking rats.