Views of American OB/GYNs on the ethics of prenatal wholegenome sequencing
Views of American OB/GYNs on the ethics of prenatal wholegenome sequencing
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DOI：
10.1002/pd.4968
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发表时间：
2016-12-01
影响因子：
3
通讯作者：
Berkman, Benjamin E.
中科院分区：
文献类型：
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作者：
Bayefsky, Michelle J.;White, Amina;Berkman, Benjamin E.
鉴于公众对遗传信息的需求，未来非侵入性产前全基因组测序（PWGS）的潜力，以及全基因组测序成本的降低，OB/GYN实践可能会包括PWGS。该项目的目标是探讨OB/GYNs的意见，对伦理问题的PWGS周围和他们的准备咨询病人在其use.Methods的全国性调查进行了管理，以2500名成员的美国国会的妇产科医师和Gynecologists.Results，共有1114名受访者完成了调查（响应率= 45%）。妇产科医生最关心的是订购非医学胎儿遗传信息，担心增加父母的焦虑，并认为这是适当的指导时，咨询父母关于PWGS。此外，大多数OB/GYNs有有限的遗传学知识，严重依赖遗传咨询师，并希望更多的指导有关的临床采用PWGS.Conclusion OB/GYNs不完全接受或拒绝PWGS，但有相当数量的重大伦理和实际问题。他们最关心的问题将直接影响他们的做法和与病人的互动，如增加父母的焦虑和护理成本。专业指引将有助指引妇产科医生采用工作指引计划，以及减轻工作指引计划对个别妇产科医生构成的道德负担。2016年出版。本条目属于美国政府作品，在美国属于公有领域。
Objective Given public demand for genetic information, the potential to perform prenatal whole-genome sequencing (PWGS) non-invasively in the future, and decreasing costs of whole-genome sequencing, it is likely that OB/GYN practice will include PWGS. The goal of this project was to explore OB/GYNs' views on the ethical issues surrounding PWGS and their preparedness for counseling patients on its use.Methods A national survey was administered to 2500 members of American Congress of Obstetricians and Gynecologists.Results A total of 1114 respondents completed the survey (response rate = 45%). OB/GYNs are most concerned with ordering non-medical fetal genetic information, are worried about increasing parental anxiety, and feel it is appropriate to be directive when counseling parents about PWGS. Furthermore, most OB/GYNs have limited knowledge of genetics, rely heavily on genetic counselors and would like more guidance regarding the clinical adoption of PWGS.Conclusion OB/GYNs do not completely accept or reject PWGS, but a substantial number have significant ethical and practical concerns. They are most concerned with issues that will directly affect their practices and interactions with patients, such as increasing parental anxiety and costs of care. Professional guidance would be instrumental in directing the adoption of PWGS and alleviating the ethical burden posed by PWGS on individual OB/GYNs. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.