Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function
Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function
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DOI：
10.2215/cjn.00070109
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发表时间：
2009-08-01
影响因子：
9.8
通讯作者：
Feldman, Harold I.
中科院分区：
文献类型：
--
作者：
Lash, James P.;Go, Alan S.;Feldman, Harold I.
背景和目标：慢性肾功能不全队列（CRIC）研究旨在检查慢性肾脏病（CKD）和心血管疾病（CVD）患者进展的风险因素。我们研究了基线人口统计学和临床特征。设计、设置、参与者和测量：七个临床中心招募了年龄在21至74岁之间的成年人，并使用基于年龄的估计GFR（eGFR）纳入标准患有CKD。在基线时，收集血液和尿液样本，并获得有关健康行为，饮食，生活质量和功能状态的信息。GFR测定使用放射性标记的iothalamate在三分之一的participator.Results：共3612名参与者登记的平均年龄+/- SD为58.2 +/- 11.0年，46%是女性，47%有糖尿病。总体而言，45%为非西班牙裔白色，46%为非西班牙裔黑人，5%为西班牙裔。86%的人报告高血压，22%的人报告冠心病，10%的人报告心力衰竭。平均体重指数为32.1 +/- 7.9 kg/m2，47%的患者血压>130/80 mmHg。平均eGFR为43.4 +/- 13.5 ml/min/1.73 m2，蛋白排泄中位数（四分位数间距）为0.17 g/24 h（0.07 - 0.81 g/24 h）。较低的eGFR与年龄较大，较低的社会经济和教育水平，吸烟，自我报告的CVD，外周动脉疾病，血压升高。结论：较低水平的eGFR与更大的负担CVD以及较低的社会经济和教育状况。参与者的长期随访将为CKD的流行病学及其与不良结局的关系提供重要见解。Clin J Am Soc Nephrol 4：1302-1311，2009. doi：10.2215/CJN.00070109
Background and objectives: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics.Design, setting, participants, & measurements: Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants.Results: A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr, 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP.Conclusions: Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes. Clin J Am Soc Nephrol 4: 1302-1311, 2009. doi: 10.2215/CJN.00070109