SUMO-specific proteases and isopeptidases of the SENP family at a glance
SUMO-specific proteases and isopeptidases of the SENP family at a glance
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DOI：
10.1242/jcs.211904
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发表时间：
2018-03-01
影响因子：
4
通讯作者：
Mueller, Stefan
中科院分区：
文献类型：
--
作者：
Kunz, Kathrin;Piller, Tanja;Mueller, Stefan
泛素相关的SUMO系统控制着许多细胞信号网络。在哺乳动物细胞中，三种SUMO形式（SUMO 1，SUMO 2和SUMO 3）作为多达数千种细胞蛋白质的共价修饰剂。SUMO结合主要通过调节蛋白质网络的可塑性来影响细胞功能。重要的是，修饰是可逆的和高度动态的。sentrinspecific protease（SENP）家族的半胱氨酸蛋白酶在哺乳动物细胞中逆转SUMO缀合。在这篇Cell Science at a Glance文章和随附的海报中，我们将总结哺乳动物SENP家族的六个成员如何协调多方面的解偶联事件以协调细胞过程，如基因表达，DNA损伤反应和炎症。
The ubiquitin-related SUMO system controls many cellular signaling networks. In mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent modifiers of up to thousands of cellular proteins. SUMO conjugation affects cell function mainly by regulating the plasticity of protein networks. Importantly, the modification is reversible and highly dynamic. Cysteine proteases of the sentrinspecific protease (SENP) family reverse SUMO conjugation in mammalian cells. In this Cell Science at a Glance article and the accompanying poster, we will summarize how the six members of the mammalian SENP family orchestrate multifaceted deconjugation events to coordinate cell processes, such as gene expression, the DNA damage response and inflammation.