Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome
Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome
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DOI：
10.1016/j.numecd.2008.12.008
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发表时间：
2009-11-01
影响因子：
3.9
通讯作者：
Herzig, K. H.
中科院分区：
文献类型：
--
作者：
Heinonen, M. V.;Laaksonen, D. E.;Herzig, K. H.
背景和目标：脂肪组织是一个活跃的内分泌器官，其分泌的信号分子参与调节胰岛素敏感性、食物摄入和炎症。爱帕琳肽是由脂肪组织分泌的肽，其已显示调节动物中的心血管张力。本研究的目的是测量饮食诱导的体重减轻后代谢综合征患者的腹部脂肪、血压和循环爱帕琳、脂联素、瘦素、生长激素释放肽、TNF-α和IL-6水平。方法和结果：35名患有代谢综合征的肥胖患者接受了8周的极低热量饮食（VLCD）和6个月的体重维持期（WM）120 mg奥利司他或安慰剂每日给药3次。VLCD和WM（-15.1 +/-1.0 kg）降低了平均动脉压（MAP）、胰岛素、瘦素、甘油三酯以及内脏和皮下脂肪组织。此外，脂联素增加，以响应重量折腾。然而，血浆爱帕琳、TNF-α和IL-6的总体变化不显著。基线时观察到血浆爱帕琳素和TNF-α之间的相关性（0.41，p < 0.05），并且血浆爱帕琳素水平的微小变化与VLCD期间的BMI以及VLCD和WM期间的MAP和TNF-α的变化相关。尽管体重减轻后BMI、身体肥胖、MAP降低，葡萄糖代谢和脂联素增强，没有观察到血浆爱帕琳、TNF-α和IL-6的显著变化。然而，apelin与TNF-α和MAP显著相关。这些结果表明，爱帕琳作为一种脂肪因子，可能与脂肪质量没有那么强的相关性，就像更丰富的脂肪因子脂联素或瘦素一样，它可能参与炎症和心血管紧张度的调节。(C)2009爱思唯尔有限公司版权所有。
Background and aims: Adipose tissue is an active endocrine organ that secretes signaling molecules involved in the regulation of insulin sensitivity, food intake and inflammation. Apelin is a peptide secreted by adipose tissue that has been shown to modulate cardiovascular tone in animals. The aim of this study was to measure abdominal fat, blood pressure and circulating apelin, adiponectin, leptin, ghrelin, TNF-alpha and IL-6 levels in patients with the metabolic syndrome after a diet-induced weight loss.Methods and results: 35 obese individuals with the metabolic syndrome underwent an 8-week very-low-calorie diet (VLCD) and a 6-month weight maintenance period (WM) with 120 mg orlistat or placebo administered 3 times daily. VLCD and WM (-15.1 +/- 1.0 kg) decreased mean arterial pressure (MAP), insulin, leptin, triglycerides and visceral and subcutaneous adipose tissue. Moreover, adiponectin increased in response to the weight toss. However, the overall changes in plasma apelin, TNF-alpha and IL-6 were non-significant. A correlation between plasma apelin and TNF-alpha was observed at baseline (0.41, p < 0.05), and the minor changes in plasma apelin levels were associated with changes in BMI during VLCD and MAP and TNF-alpha during VLCD and WM, periods.Conclusion: Despite reductions in BMI, body adiposity, MAP and enhancement of glucose metabolism and adiponectin in response to weight toss, no significant changes in plasma apelin, TNF-alpha and IL-6 were observed. However, apelin significantly correlated with TNF-alpha and MAP. These results suggest that apelin may not be that strongly correlated with the fat mass as an adipokine like the more abundant adipokines adiponectin or leptin and it might be involved in the regulation of inflammation and cardiovascular tone. (C) 2009 Elsevier B.V. All rights reserved.