Longevity of exercising male rats: effect of an antioxidant supplemented diet
Longevity of exercising male rats: effect of an antioxidant supplemented diet
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DOI：
10.1016/s0047-6374(97)00140-1
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发表时间：
1998-02-16
影响因子：
5.3
通讯作者：
Holloszy, JO
中科院分区：
文献类型：
--
作者：
Holloszy, JO
食物限制延长了啮齿动物的最长寿命。在自愿跑轮上锻炼的雄性大鼠，尽管存在相对的热量不足，但最长寿命并没有增加。相比之下，久坐不动的大鼠如果受到食物限制，从而导致同样的卡路里不足，那么它们的最长寿命就会延长。运动引起的氧化应激似乎有可能阻止卡路里缺乏的最大延长寿命的效果显现出来。这项研究是为了确定抗氧化剂是否会让运动的最大延寿效果在雄性大鼠身上表现出来。抗氧化剂饮食对跑步者(951+/-158天比对照组937+/-171天)或久坐对照组(875+/-127比858+/-152天)寿命没有影响。与之前的研究一样，车轮运动适度地延长了平均寿命(约为9%)，但对最长寿命没有影响。抗氧化剂对跑轮者的寿命没有影响的发现支持了一种解释，即运动导致的雄性大鼠卡路里缺乏没有延长寿命的效果，而氧化组织损伤可以抵消这种作用。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
Food restriction increases maximal life span in rodents. Male rats that exercise in voluntary running wheels do not have an increase in maximal longevity despite a relative caloric deficit. In contrast, sedentary rats that are food restricted so as to cause the same caloric deficit have an extension of maximal longevity. It seemed possible that exercise-induced oxidative stress might prevent a maximum life span-extending effect of a caloric deficit to manifest itself. This study was done to determine if antioxidants would allow a maximal longevity-extending effect of exercise to manifest itself in male rats. The antioxidant diet had no effect on longevity of the runners (Antiox., 951+/-158 days versus control 937+/-171 days), or of the sedentary controls (875 +/- 127 versus 858 +/- 152 days). As in previous studies, wheel running modestly increased average longevity (approximate to 9%), but had no effect on maximal life span. The finding that antioxidants had no effect on longevity of the wheel runners supports the interpretation that the caloric deficit induced by exercise in male rats does not have a life-extending effect that is countered by oxidative tissue damage. (C) 1998 Elsevier Science ireland Ltd. All rights reserved.