Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions.
Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions.
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DOI：
10.1016/j.jid.2017.10.025
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Paus R
中科院分区：
文献类型：
--
作者：
Slominski AT;Hardeland R;Zmijewski MA;Slominski RM;Reiter RJ;Paus R
褪黑激素是一种具有激素性质的5-羟色胺的古老衍生物，是松果体的主要神经内分泌产物。虽然褪黑激素是最有名的调节昼夜节律和降低脊椎动物的皮肤色素沉着，这种自由基清除分子，也诱导/促进复杂的抗氧化和DNA修复系统，包括免疫调节，体温调节和抗肿瘤特性的功能活动的全谱。由于这种过多的功能褪黑激素的属性仍然等待皮肤科医生充分认识，目前的审查综合的主要特点，使褪黑激素一个有前途的候选人与大量的氧化损伤相关的几种皮肤病的管理。我们还审查了为什么承诺是有用的皮肤癌的预防，皮肤的光和辐射防护，并作为一种诱导剂的修复机制，促进人类皮肤从环境损害的恢复。人类皮肤和毛囊不仅表达功能性褪黑激素受体，而且还参与大量的松果体外褪黑激素合成，这一事实进一步鼓励人们系统地探索皮肤的褪黑激素系统如何在未来的临床皮肤病学中成为治疗靶点，并参与预防医学策略。
Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. Although melatonin is best known to regulate circadian rhythmicity and lower vertebrate skin pigmentation, the full spectrum of functional activities of this free radical-scavenging molecule, which also induces/promotes complex antioxidative and DNA repair systems, includes immunomodulatory, thermoregulatory, and antitumor properties. Because this plethora of functional melatonin properties still awaits to be fully appreciated by dermatologists, the current review synthesizes the main features that render melatonin a promising candidate for the management of several dermatoses associated with substantial oxidative damage. We also review why promises to be useful in skin cancer prevention, skin photo- and radioprotection, and as an inducer of repair mechanisms that facilitate the recovery of human skin from environmental damage. The fact that human skin and hair follicles not only express functional melatonin receptors but also engage in substantial, extrapineal melatonin synthesis further encourages one to systematically explore how the skin’s melatonin system can be therapeutically targeted in future clinical dermatology and enrolled for preventive medicine strategies.
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影响因子：
5.6
作者：
Carrillo-Vico A;Lardone PJ;Alvarez-Sánchez N;Rodríguez-Rodríguez A;Guerrero JM
通讯作者：
Guerrero JM
影响因子：
10.3
作者：
Fischer, Tobias W.;Kleszczynski, Konrad;Zillikens, Detlef
通讯作者：
Zillikens, Detlef
影响因子：
64.5
作者：
Farez MF;Mascanfroni ID;Méndez-Huergo SP;Yeste A;Murugaiyan G;Garo LP;Balbuena Aguirre ME;Patel B;Ysrraelit MC;Zhu C;Kuchroo VK;Rabinovich GA;Quintana FJ;Correale J
通讯作者：
Correale J
影响因子：
11.2
作者：
Ahn, Kwang Seok;Gong, Xing;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
10.3
作者：
Cabrera, Javier;Negrin, Gledy;Quintana, Jose
通讯作者：
Quintana, Jose