VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells
VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells
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DOI：
10.1016/j.cellimm.2012.07.009
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发表时间：
2012-07-01
影响因子：
4.3
通讯作者：
Han, Wenling
中科院分区：
文献类型：
--
作者：
Guo, Xiaohuan;Zhang, Yanfei;Han, Wenling
细胞因子是介导免疫反应的可溶性蛋白，负责免疫细胞之间的通讯。CD4(+) T细胞是适应性免疫细胞因子的主要来源。细胞因子在CD4(+) T细胞的分化和效应功能中起关键作用。它们在疾病中也起着关键作用，其中一些已以重组细胞因子、可溶性受体和中和抗体的形式开发成药物。因此，发现新的潜在细胞因子对于更好地理解免疫学和增进人类健康是必要的和有益的。为了寻找新的潜在细胞因子，我们对整个人类基因组进行了综合生物信息学分析。筛选候选细胞因子进行cDNA克隆、亚克隆、分泌验证、表达谱分析和功能研究。在这里，我们报告了一种新的可溶性蛋白。VSTM1-v2是一种主要表达于免疫组织的经典分泌性糖蛋白，可促进Th17细胞的分化和活化。(C) 2012爱思唯尔公司版权所有。
Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in diseases, and some of them have been developed into drugs in the forms of recombinant cytokines, soluble receptors and neutralizing antibodies. Therefore, identifying novel potential cytokines is necessary and beneficial for better understanding immunology and enhancing human health. To find novel potential cytokines, we carried out an integrated bioinformatics analysis on the whole human genome. Cytokine candidates were selected for cDNA cloning, sub-cloning, secretion verification, expression profile analysis and functional study. Here, we report a novel soluble protein. VSTM1-v2, which is a classical secretory glycoprotein mainly expressed in immune tissues, and can promote the differentiation and activation of Th17 cells. (C) 2012 Elsevier Inc. All rights reserved.