'Curing' empty follicle syndrome
'Curing' empty follicle syndrome
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DOI：
10.1093/humrep/12.1.21
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发表时间：
1997-01-01
影响因子：
6.1
通讯作者：
Green, S
中科院分区：
文献类型：
--
作者：
Ndukwe, G;Thornton, S;Green, S
我们报告了一种新的方法来挽救空卵泡综合征（EFS），并提供证据表明，这是一个药物相关的问题，而不是一个临床功能障碍，在一项初步研究中，我们建立了在EFS的血清β-人绒毛膜促性腺激素HCG给药后36 h的β-HCG浓度从未超过10 mIU/ ml，因此，当控制性超促排卵后仅从一个卵巢中未回收卵母细胞时，β-HCG浓度用于确认EFS。暂停该程序，使第二个卵巢中的所有卵泡保持完整。在确认EFS后，给予来自不同批次的第二种HCG，36 h后从完整卵巢中取出成熟卵母细胞，表明先前给予的HCG存在缺陷。三名患者接受了这种治疗，在第一种情况下，五个成熟卵子中的四个在卵胞浆内单精子注射（ICSI）后受精，导致三个顶级（1级）胚胎的移植，在第二种情况下，所有七个体外受精（IVF）后受精的成熟卵母细胞和三个1级胚胎被移植，导致双胞胎妊娠，现在分娩，在第三种情况下，9个卵母细胞中的5个在ICSI后受精，3个用高授精浓度IVF处理的卵母细胞中的1个受精，导致3个ICSI胚胎的移植。
We report a novel method of rescuing empty follicle syndrome (EFS) and provide evidence that it is a drug-related problem rather than a clinical dysfunction, In a preliminary study we established that in EFS the serum beta-human chorionic gonadotrophin (beta-HCG) concentrations 36 h after HCG administration never exceeded 10 mIU/ ml, beta-HCG concentrations were thus used to confirm EFS when oocytes mere not retrieved from one ovary after controlled ovarian hyperstimulation, The procedure was suspended leaving intact all follicles in the second ovary. After confirmation of EFS, a second HCG from a different batch was administered and 36 h later mature oocytes were retrieved from the intact ovary, suggesting a fault with the HCG previously administered. Three patients have been treated in this way, In the first case, four out of five mature eggs were fertilized after intracytoplasmic sperm injection (ICSI) resulting in the transfer of three top grade (grade 1) embryos, In the second case all seven mature oocytes fertilized after in-vitro fertilization (IVF) and three grade 1 embryos were transferred resulting in a twin pregnancy, now delivered, In the third case, five out of nine oocytes were fertilized after ICSI and one out of the three treated with high insemination concentration IVF fertilized, resulting in the transfer of three ICSI embryos.