Exacerbation of liver steatosis following exposure to famine and overnutrition
Exacerbation of liver steatosis following exposure to famine and overnutrition
复制标题
饥荒和营养过剩后肝脏脂肪变性加剧
DOI：
10.1002/mnfr.201700097
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发表时间：
2017-10-01
影响因子：
5.2
通讯作者：
Lu, Yingli
中科院分区：
文献类型：
--
作者：
Ning, Zhiyuan;Zhang, Kun;Lu, Yingli
范围：在早期生活中遭受饥荒和成年后营养过剩的人可能会增加肝脏脂肪变性的风险。我们的目的是探讨早期营养限制和过度营养对从头脂肪genesinliver.Methods和结果的影响和机制：3周龄雄性大鼠限食4周，并分别在代谢笼中喂高脂或正常脂肪饮食9周。还设立了体重匹配组。测量脂肪酸合成酶表达以估计肝脏中的从头脂肪生成。用同位素分析法测定糖脂代谢参数。所有四组的体重相当。然而，饥荒高脂饮食组的肝脏脂肪变性程度最高、体脂比最大、胰岛素抵抗最高。饥饿组和高脂饮食组的肝脏脂质积累、脂肪酸合成酶表达和脂肪生成显著高于对照组（p < 0.05）。结论：在饥饿和高脂再喂养应激条件下，大鼠极易发生肝脂肪变性。这可能是从头脂肪生成上调和从肌肉到肝脏从头脂肪生成的葡萄糖通量增强的结果。
Scope: People suffering from famine in early life and overnutrition in adulthood may have an increased risk for liver steatosis. We aimed to investigate the effects and mechanisms of early nutrition restriction and overnutrition on de novo lipogenesis in the liver.Methods and results: Three-wk-old male rats were food restricted for 4 wk and refed a high-fat or normal fat diet individually in metabolic cages for 9 wk. Weight-matched groups were also set up. Fatty acid synthetase expression was measured to estimate de novo lipogenesis in the liver. Parameters of glucose and lipid metabolism were measured with isotope assays. All four groups had comparable body weights. However, the famine high-fat diet group had the highest degree of liver steatosis, the greatest body fat ratio, and insulin resistance. Lipid accumulation, fatty acid synthetase expression, and gluconeogenesis in the liver were significantly higher in the famine and high-fat diet groups (p < 0.05). Moreover, these groups also had markedly lower muscle glucose uptake.Conclusion: Under famine and high-fat refeeding stress, rats were extremely susceptible to developing hepatic steatosis. This is presumably a consequence of upregulation of de novo lipogenesis and enhanced glucose flux from muscle to de novo lipogenesis in the liver.