Environmental and occupational disorders Housing characteristics, reported mold exposure, and asthma in the European Community Respiratory Health Survey
Environmental and occupational disorders Housing characteristics, reported mold exposure, and asthma in the European Community Respiratory Health Survey
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发表时间：
2002
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通讯作者：
PhD Jan-Paul Zock;MD Deborah Jarvis;PhD Christina Luczynska;MD Jordi Sunyer;MD Peter Burney
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作者：
PhD Jan-Paul Zock;MD Deborah Jarvis;PhD Christina Luczynska;MD Jordi Sunyer;MD Peter Burney
背景：室内潮湿和霉菌暴露对成人哮喘的影响尚不清楚。目的：我们旨在调查来自欧洲共同体呼吸健康调查的38个研究中心的与潮湿、霉菌暴露和室内尘螨水平相关的住房特征与成人哮喘之间的关系。方法：通过问卷调查的方式获取现有家庭、供暖和通风系统、双层玻璃、地板覆盖物、近期水害和霉菌暴露的数据。这些因素与哮喘（根据去年的症状定义）和支气管反应性（根据甲胆碱挑战确定）之间的关系进行了评估。优势比（ORs）通过在研究中心内对性别、年龄组和吸烟状况进行调整的随机效应荟萃分析获得。结果：卧室铺有地毯和地毯与哮喘症状和支气管反应性减少相关（OR范围：0.69 ~ 0.91）。这种影响在各个中心是一致的，在室内尘螨敏感的个体中更为明显。去年报告的霉菌暴露与哮喘症状和支气管反应性有关（OR范围，1.14-1.44）。这种效应在中心间是均匀的，在对枝孢菌敏感的受试者中更强。在哮喘患病率较高的中心，报告的室内霉菌暴露的患病率也很高。哮喘受试者报告的霉菌暴露（Spearman r = 0.46）和非哮喘受试者报告的霉菌暴露（r = 0.54）均观察到这种关联。据报道，霉菌暴露在最近遭受水破坏的老房子中最高。结论：室内霉菌生长对成人哮喘有不良影响。[J]过敏症临床与免疫杂志2002；11:285-92。
Background: The effects of home dampness and mold exposure on adult asthma are not clear. Objective: We aimed to investigate the associations between housing characteristics related to dampness, mold exposure, and house dust mite levels and adult asthma in 38 study centers from the European Community Respiratory Health Survey. Methods: Data about the present home, heating and ventilation systems, double glazing, floor covers, recent water damage, and mold exposure were obtained by means of an inter-viewer-led questionnaire. The associations between these factors and asthma, as defined on the basis of symptoms in the last year, and of bronchial responsiveness, as determined with methacholine challenge, were evaluated. Odds ratios (ORs) were obtained by using random-effects meta-analyses adjusted within study centers for sex, age group, and smoking status. Results: Fitted carpets and rugs in the bedroom were related to fewer asthma symptoms and bronchial responsiveness (OR range, 0.69-0.91). This effect was consistent across centers and more pronounced among house dust mite–sensitized individuals. Reported mold exposure in the last year was associated with asthma symptoms and bronchial responsiveness (OR range, 1.14-1.44). This effect was homogeneous among centers and stronger in subjects sensitized to Cladosporium species. In centers with a higher prevalence of asthma, the prevalence of reported indoor mold exposure was also high. This association was observed for reported mold exposure by asthmatic subjects (Spearman r s = 0.46), as well as reported mold exposure by nonasthmatic subjects ( r s = 0.54). Reported mold exposure was highest in older houses with recent water damage. Conclusion: We conclude that indoor mold growth has an adverse effect on adult asthma. (J Allergy Clin Immunol 2002;110:285-92.)