Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus
Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus
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DOI：
10.1021/np020518b
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发表时间：
2003-05-01
影响因子：
5.1
通讯作者：
Wright, AD
中科院分区：
文献类型：
--
作者：
Abdel-Lateff, A;Klemke, C;Wright, AD
一种海洋真菌分离物，鉴定为Wardomenopterus，被培养并发现除了已知的氧杂蒽酮衍生物3，6外，还产生两种新的氧杂蒽酮衍生物，2，3，6，8-四羟基-1-甲基氧杂蒽酮（1）和2，3，4，6，8-五羟基-1-甲基氧杂蒽酮（2），8-三羟基-1-甲基氧杂蒽酮（3）和已知的真菌代谢物5-（羟甲基）-2-呋喃羧酸（4）。所有化合物的结构都是基于广泛的光谱测量（1D和2D NMR、MS、UV和IR）来确定的。化合物1和4显示出明显的抗氧化活性。总提取物和1、3、4显示为p56（lck）酪氨酸激酶抑制剂。
A marine fungal isolate, identified as Wardomyces anomalus, was cultivated and found to produce two new xanthone derivatives, 2,3,6,8-tetrahydroxy-1-methylxanthone (1) and 2,3,4,6,8-pentahydroxy-1-methylxanthone (2), in addition to the known xanthone derivative 3,6,8-trihydroxy-1-methylxanthone (3) and the known fungal metabolite 5-(hydroxymethyl)-2-furanocarboxylic acid (4). The structures of all compounds were determined on the basis of extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). Compounds 1 and 4 showed significant antioxidant activities. The total extract and 1, 3, and 4 were shown to be inhibitors of p56(lck) tyrosine kinase.