Differences of Ca2+ regulation between fibroblasts from blacks and whites.
Differences of Ca2+ regulation between fibroblasts from blacks and whites.
复制标题
黑人和白人成纤维细胞 Ca2+ 调节的差异。
DOI：
10.1093/ajh/2.2.105
复制
发表时间：
1989
影响因子：
3.2
通讯作者：
Aviv,A
中科院分区：
文献类型：
--
作者：
Nakamura,A;Hatori,N;Nakamura,M;Fine,BP;Aviv,A
为了探讨黑人易患原发性高血压的潜在原因，我们研究了血压正常的黑人和白人静止期皮肤成纤维细胞中45 Ca 2+洗脱和胞浆游离Ca 2+（Cai 2+）。在基础条件下，45 Ca ~（2+）的洗脱率和Ca ~（2+）的去除率没有种族差异。然而，当受人血清刺激时，黑人成纤维细胞比白人成纤维细胞表现出更高的45 Ca 2+洗脱，与更高水平的Cai 2+瞬变相关。我们的结论是，从黑人的成纤维细胞表现出增加的反应，在血清中的激动剂。如果在血管平滑肌细胞中也存在同样的趋势，则可能使黑人易患原发性高血压。美国高血压杂志1989;2：105-107
To explore the underlying causes predisposing blacks to essential hypertension, we have studied45Ca2+washout and cytosolic free Ca2+(Cai2+) in quiescent skin fibroblasts from normotensive blacks and whites. Under basal conditions, there were no racial differences in45Ca2+washout and Cai2+. However, when stimulated by human serum, fibroblasts from blacks exhibited a higher45Ca2+washout associated with higher levels of Cai2+transients than fibroblasts from whites. We conclude that fibroblasts from blacks demonstrate increased responsiveness to agonists in serum. if the same trend exists in vascular smooth muscle cells, it may predispose blacks to essential hypertension. Am J Hypertens 1989;2:105–107