Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders
Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders
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DOI：
10.1002/aur.218
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发表时间：
2011-12-01
期刊：
影响因子：
4.7
通讯作者：
Deutsch, Stephen I.
中科院分区：
文献类型：
--
作者：
Jacome, Luis F.;Burket, Jessica A.;Deutsch, Stephen I.
Balb/c小鼠被认为是具有明显社交缺陷的人类疾病的模型，如自闭症谱系障碍（asd），可能涉及NMDA受体介导的神经传递的病理生理破坏。采用标准程序测量8周龄雄性遗传近交Balb/c小鼠和远交Swiss Webster小鼠的社交能力。此外，由于社交能力受损可能会影响刺激小鼠的社交行为，我们还测量了在允许测试小鼠和刺激小鼠自由互动的情况下，刺激小鼠的社交行为总次数的比例。三名评分者具有良好的评分一致性，他们评估了操作性定义的社交能力指标，因为他们的描述与asd患者报告的社交行为缺陷相似。这些数据支持了先前的报道，即Balb/c小鼠是一种社交能力受损的遗传小鼠模型。这些数据还表明，社交刺激小鼠的行为受到Balb/c品系社交能力受损的影响。有趣的是，在小鼠品系中，操作性定义的社交性指标并不一定相互关联，而且品系之间相关指标的概况也有所不同。最后，在测试与社会刺激小鼠的自由互动过程中，Swiss Webster比Balb/c小鼠表现出更强烈的刻板行为（即抚养、梳理和爬墙），这表明Balb/c品系的社交性领域和限制性重复和刻板行为模式是相互独立的。自闭症研究，2011,(4):393400。(C) 2011年国际自闭症研究学会，北京：中国科学研究院。
The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, stereotypic behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and restricted repetitive and stereotyped patterns of behavior are independent of each other in the Balb/c strain. Autism Res 2011,4:393400. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc.