Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats.
Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats.
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DOI：
10.1292/jvms.15-0104
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Shimoda M
中科院分区：
文献类型：
--
作者：
Elbadawy M;Sasaki K;Miyazaki Y;Aboubakr M;Khalil WF;Shimoda M
研究了对乙酰氨基酚给药后对柴山羊胃排空的药代动力学，以评价其胃排空特性。对乙酰氨基酚按30 mg/kg体重静脉注射和口服，采用交叉设计，洗脱期为3周。对乙酰氨基酚在瘤胃液中的稳定性也进行了评价。用高效液相色谱法测定对乙酰氨基酚浓度。由于对乙酰氨基酚在瘤胃液中稳定24小时，其极低的生物利用度（16%）归因于其肝脏广泛的首过效应。平均吸收时间和吸收半衰期出乎意料地短（分别为4.93和3.35小时），表明其从前胃吸收明显，这可能是由于其较小的分子量。因此，对乙酰氨基酚不适合用于评价柴山羊胃排空。
The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The stability of acetaminophen in rumen juice was also assessed. Acetaminophen concentrations were measured by HPLC. Since acetaminophen was stable in rumen juice for 24 hr, the extremely low bioavailability (16%) was attributed to its hepatic extensive first-pass effect. The mean absorption time and absorption half-life were unexpectedly short (4.93 and 3.35 hr, respectively), indicating its marked absorption from the forestomach, which may have been due to its smaller molecular weight. Therefore, acetaminophen was considered to be unsuitable for evaluating gastric emptying in Shiba goats.