Time trends in the incidence of parkinsonism in Olmsted County, Minnesota
Time trends in the incidence of parkinsonism in Olmsted County, Minnesota
复制标题
DOI：
10.1212/wnl.57.3.462
复制
发表时间：
2001-08-14
期刊：
影响因子：
9.9
通讯作者：
Maraganore, DM
中科院分区：
文献类型：
--
作者：
Rocca, WA;Bower, JH;Maraganore, DM
目的：研究15年（1976 - 1990）期间帕金森综合征和帕金森病发病率的时间趋势。研究方法：作者使用罗切斯特流行病学项目的病历联系系统，确定了明尼苏达州奥姆斯特德县1976年至1980年、1981年至1985年和1986年至1990年三个5年期间帕金森症的发病病例。使用定义的标准对PD和其他类型的帕金森综合征进行分类。人口统计学因子来自人口普查数据，并通过删除帕金森综合征的流行病例进行校正。结果：在15年的研究中，确定了364例帕金森综合征，其中154例（42%）患有PD。在0 - 39岁、40 - 59岁和60 - 69岁年龄组的3个5年期间，帕金森综合征的发病率保持稳定。对于70至99岁年龄组，随着时间的推移有所增加，主要是由于药物引起的帕金森症的发生率增加。所有年龄组的PD发生率在3个5年期间保持稳定。当分别考虑男性和女性时，结果相似。帕金森综合征无出生队列效应。与之前在同一人群中进行的三项研究进行比较，并未发现帕金森病发病率的任何重大长期趋势。结论：超过15年的PD研究结果以及与半个世纪以来帕金森症历史数据的比较表明，没有PD的主要环境风险因素（例如，环境毒素、药物、饮食成分或传染因子）在这些时期被引入或从该人群中移除。
Objective: To investigate time trends in the incidence of parkinsonism and PD over a 15-year period (1976 to 1990). Methods: The authors used the medical records-linkage system of the Rochester Epidemiology Project to identify incidence cases of parkinsonism in Olmsted County, MN, over three 5-year periods, 1976 to 1980, 1981 to 1985, and 1986 to 1990. PD and other types of parkinsonism were classified using defined criteria. Population denominators were derived from census data and were corrected by removing prevalent cases of parkinsonism. Results: Over the 15 years of the study, 364 cases of parkinsonism were identified; 154 (42%) of them had PD. The incidence of parkinsonism remained stable over the three 5-year periods for the age classes 0 to 39, 40 to 59, and 60 to 69 years. For the age class 70 to 99 years, there was some increase over time mainly owing to an increased incidence of drug-induced parkinsonism. The incidence of PD remained stable over the three 5-year periods for all age classes. Results were similar when considering men and women separately. No birth-cohort effect was present for parkinsonism. Comparison with three previous studies in the same population did not reveal any major long-term secular trends in the incidence of parkinsonism. Conclusions: The findings for PD over 15 years and comparison of the findings with historical data for parkinsonism over half a century suggest that no major environmental risk factors for PD (e.g., environmental toxins, drugs, diet constituents, or infectious agents) were introduced or removed from this population during these periods.