Fluid resuscitation therapy for paediatric sepsis
Fluid resuscitation therapy for paediatric sepsis
复制标题
小儿脓毒症的液体复苏治疗
DOI：
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发表时间：
2016
影响因子：
1.7
通讯作者：
T. Duke
中科院分区：
文献类型：
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作者：
Elliot Long;T. Duke
败血症和感染性休克是许多失代偿期儿科感染的最终共同途径。液体复苏疗法一直是这些儿童血流动力学复苏的基石。有充分的证据证明0.9%的生理盐水和4%的白蛋白相当，而后者的相对费用更高，这意味着0.9%的生理盐水是目前世界上最常用的复苏液。有证据表明，0.9%生理盐水中氯负荷的危害引起了人们对平衡溶液作为一线复苏液的兴趣。它们的安全性已经在观察研究中得到了很好的证实，它们很可能是最合理的复苏默认液体。半合成胶体与肾功能障碍和死亡有关，应避免使用。有证据表明，过度使用任何复苏液体都会造成伤害。复苏液量的处理应与任何其他静脉给药的剂量相同，并在给药前权衡对个体患者的潜在益处和危害。
Sepsis and septic shock are the final common pathway for many decompensated paediatric infections. Fluid resuscitation therapy has been the cornerstone of haemodynamic resuscitation in these children. Good evidence for equivalence between 0.9% saline and 4% albumin, with the relative expense of the latter, has meant that 0.9% saline is currently the most commonly used resuscitation fluid world‐wide. Evidence for harm from the chloride load in 0.9% saline has generated interest in balanced solutions as first line resuscitation fluids. Their safety has been well established in observational studies, and they may well be the most reasonable default fluid for resuscitation. Semi‐synthetic colloids have been associated with renal dysfunction and death and should be avoided. There is evidence for harm from excessive administration of any resuscitation fluid. Resuscitation fluid volumes should be treated in the same way as the dose of any other intravenously administered medication, and the potential benefits versus harms for the individual patient weighed prior to administration.
影响因子：
37.8
作者：
de Caen, Allan R.;Maconochie, Ian K.;Pintos, Remigio Veliz
通讯作者：
Pintos, Remigio Veliz