IgE, mast cells, basophils, and eosinophils.

IgE, mast cells, basophils, and eosinophils.
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DOI:
10.1016/j.jaci.2009.11.017
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发表时间:
2010-02
影响因子:
14.2
通讯作者:
Metcalfe, Dean D.
Metcalfe, Dean D.
中科院分区:
医学1区
文献类型:
--
作者:
Stone, Kelly D.;Prussin, Calman;Metcalfe, Dean D.

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IgE、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞是过敏性炎症的基本成分。通过肥大细胞和嗜碱性粒细胞上的εRI受体与Ig E结合,产生抗原特异性的Ig E,是即刻超敏反应的启动和繁殖的中心环节。肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞是过敏性炎症以及先天免疫和获得性免疫的中心效应细胞。这篇综述重点介绍了这些成分及其在疾病发病机制中的作用。
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
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