Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital
Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital
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中国某大学附属医院喹诺酮类耐药鲍曼不动杆菌中bla(OXA-23)与armA的共存
DOI：
10.1016/j.diagmicrobio.2015.10.009
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发表时间：
2016-03-01
影响因子：
2.9
通讯作者：
Jia, Xu
中科院分区：
文献类型：
--
作者：
Shen, Min;Luan, Guangxin;Jia, Xu
收集101株鲍曼不动杆菌，分析其喹诺酮耐药机制，并调查喹诺酮耐药菌株中碳青霉烯类和高水平氨基糖苷类耐药基因的发生情况。在77株含有gyrA和parC突变的耐喹诺酮鲍曼不动杆菌中，有41株属于欧洲克隆II，由于armA的表达和bla（OXA-23）的获得而对氨基糖苷类和碳青霉烯类产生耐药性。大部分序列类型属于克隆复合体92。这些结果提示携带bla（OXA-23）、armA的多药鲍曼不动杆菌在中国西部的医院传播以及喹诺酮类药物耐药地区的突变。(C) 2016 Elsevier Inc.版权所有。
A total of 101 Acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. Among 77 quinolone-resistant A. baumannii harbored mutations of gyrA and parC, 41 isolates, which belonged to European clone II, had resistance to aminoglycosides and carbapenems due to the expression of armA and acquisition of bla(OXA-23). Most of sequence type belonged to clonal complex 92. These results suggested hospital dissemination of multidrug-resistant A. baumannii carrying bla(OXA-23), armA, and mutations of quinolone resistance-determining regions in western China. (C) 2016 Elsevier Inc. All rights reserved.