Molecular and epidemiologic analysis of dengue virus isolates from Somalia
Molecular and epidemiologic analysis of dengue virus isolates from Somalia
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DOI：
10.3201/eid0402.980220
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发表时间：
1998-04-01
影响因子：
11.8
通讯作者：
Hoke, CH
中科院分区：
文献类型：
--
作者：
Kanesa-thasan, N;Chang, GJJ;Hoke, CH
对1993年从索马里发热士兵中分离的14株登革病毒（13株登革2型病毒和1株登革3型病毒）进行了核苷酸序列分析。登革热病毒与1984年在索马里发现的登革热2型病毒关系最为密切。然而，核苷酸序列的差异（0.35%至1.35%）之间的1993年分离株是明显的。这些差异与感染的地理位置以及同一地点感染的不同时间密切相关。菌株之间的遗传差异与临床特征的差异无关。登革病毒的分子分析是流行病学调查其分布的距离和时间的有用辅助手段。
Nucleotide sequence analysis was performed on 14 dengue virus isolates (13 dengue-2 viruses and 1 dengue-3 virus) recovered from febrile soldiers in Somalia in 1993. The dengue-e viruses were most closely related to dengue-2 virus recovered in Somalia in 1984. However, differences in nucleotide sequence (0.35% to 1.35%) were evident among the 1993 isolates. These differences were closely associated with the geographic location of the infection as well as with different times of infection at the same location. Genetic difference between strains was not associated with differences in clinical features. Molecular analysis of dengue viruses is a useful adjunct to epidemiologic investigation of their distribution over distance and time.