Coalescent processes when the distribution of offspring number among individuals is highly skewed
Coalescent processes when the distribution of offspring number among individuals is highly skewed
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DOI：
10.1534/genetics.105.052175
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发表时间：
2006-04-01
期刊：
影响因子：
3.3
通讯作者：
Wakeley, J
中科院分区：
文献类型：
--
作者：
Eldon, B;Wakeley, J
我们报告了一组复杂的比例关系之间的突变和繁殖在一个简单的模型的人口。这些都来自于对DNA序列样本中遗传多样性模式的考虑。五种不同的极限过程，每一种都有不同的突变参数，可以用来描述大种群的遗传多样性。其中只有一个对应于通常的群体遗传模型，其他模型对遗传多样性做出了截然不同的预测。复杂性的出现是因为个体可能有很多后代。在某种程度上，这发生在一个给定的物种，我们的结果意味着，根据通常的假设下，遗传数据的推论可能是错误的。我们的研究结果还揭示了世代重叠的人群和世代离散的人群之间的根本差异。我们从五个极限过程中选择一个。似乎是适当的一些海洋生物，并使用一个样本的遗传数据从人口太平洋牡蛎推断模型的参数。这些数据表明存在罕见的繁殖事件，其中约8%的种群被单个个体的后代所取代。
We report a complex set of scaling relationships between mutation and reproduction in a simple model of a Population. These follow from a consideration of patterns of genetic diversity in a sample of DNA sequences. Five different possible limit processes, each with a different scaled mutation parameter, call be used to describe genetic diversity in a large population. Only one of these corresponds to the usual Population genetic model, and the others make drastically different predictions about genetic diversity The complexity arises because individuals call potentially have very many offspring. TO the extent that this occurs in a given species, our results imply that inferences from genetic data Made under the usual assumptions are likely to be wrong. Our results also uncover a fundamental difference between populations in which generations are overlapping and those in which generations are discrete. We choose one of the five limit processes that. appears to be appropriate for some marine organisms and use a sample of genetic data from a population Of Pacific oysters to infer the parameters of the model. The data suggest the presence of rare reproduction events in which similar to 8% of the Population is replaced by the offspring of a single individual.