An exploratory analysis of the competing effects of alcohol use and advanced hepatic fibrosis on serum HDL.
An exploratory analysis of the competing effects of alcohol use and advanced hepatic fibrosis on serum HDL.
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DOI：
10.1007/s10238-021-00736-6
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发表时间：
2022-03
影响因子：
4.6
通讯作者：
Luther J
中科院分区：
文献类型：
--
作者：
Vannier AGL;PeBenito A;Fomin V;Chung RT;Schaefer E;Goodman RP;Luther J
虽然酒精使用已被证明会增加血清高密度脂蛋白，但晚期肝病与血清高密度脂蛋白的降低有关。饮酒和肝纤维化的综合影响还不明确。在这项研究中，我们试图调查酒精使用和肝纤维化对血清HDL的竞争效应，并确定晚期肝纤维化的存在是否会削弱已报道的酒精消耗对血清HDL的影响。我们对来自Partners Biobank的10,528例患者进行了横断面探索性分析，检查了酒精使用与晚期肝纤维化之间的相互作用，以及血清HDL水平。采用FIB-4指数评估肝纤维化。我们排除了具有影响血清HDL的基线特征、独立于酒精使用或存在或晚期肝纤维化的患者。我们观察到HDL水平的增加与饮酒量之间存在逐渐增加的相关性（P < 0.0001），在每天喝1-2杯酒的个体中，HDL水平趋于稳定。相反，我们发现晚期肝纤维化与较低HDL水平之间存在负相关，与饮酒无关（β系数：-0.011075,SEM0.003091， P值：0.0001）。最后，当比较不饮酒和饮酒的晚期肝纤维化患者时，我们观察到饮酒与HDL水平升高相关（54.58 mg/dL vs 67.26 mg/dL, p = 0.0009）。与无晚期肝纤维化证据的患者相比，酒精的hdl升高作用更为明显（60.88 mg/dL vs 67.93 mg/dL, p < 0.0001）。我们的数据表明，晚期肝纤维化的存在并没有减弱酒精使用的hdl升高作用。
While alcohol use has been shown to increase serum HDL, advanced liver disease associates with decreased serum HDL. The combined influence of alcohol consumption and liver fibrosis is poorly defined. In this study, we sought to investigate the competing effects of alcohol use and hepatic fibrosis on serum HDL and to determine if the presence of advanced hepatic fibrosis ablates the reported effect of alcohol consumption on serum HDL. We performed a cross-sectional, exploratory analysis examining the interaction between alcohol use and advanced hepatic fibrosis on serum HDL levels in 10,528 patients from the Partners Biobank. Hepatic fibrosis was assessed using the FIB-4 index. We excluded patients with baseline characteristics that affect serum HDL, independent of alcohol use or the presence or advanced hepatic fibrosis. We observed an incremental correlation between increasing HDL levels and amount of alcohol consumed (P < 0.0001), plateauing in those individuals who drink 1–2 drinks per day, Contrastingly, we found a negative association between the presence of advanced hepatic fibrosis and lower HDL levels, independent of alcohol use (beta coefficient: -0.011075, SEM0.003091, P value: 0.0001). Finally, when comparing subjects with advanced hepatic fibrosis who do not use alcohol to those who do, we observed that alcohol use is associated with increased HDL levels (54.58 mg/dL vs 67.26 mg/dL, p = 0.0009). This HDL-elevating effect of alcohol was more pronounced than that seen in patients without evidence of advanced hepatic fibrosis (60.88 mg/dL vs 67.93 mg/dL, p < 0.0001). Our data suggest that the presence of advanced hepatic fibrosis does not blunt the HDL-elevating effect of alcohol use.
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影响因子：
3.7
作者：
Butt，Adeel A.;Yan，Peng;Abou-Samra，Abdul-Badi
通讯作者：
Abou-Samra，Abdul-Badi
影响因子：
29.4
作者：
JAHN, CE;SCHAEFER, EJ;BREWER, HB
通讯作者：
BREWER, HB
影响因子：
--
作者：
Gainer, Vivian S.;Cagan, Andrew;Murphy, Shawn N.
通讯作者：
Murphy, Shawn N.
影响因子：
12.6
作者：
Simon, Tracey G.;Henson, Jacqueline;Corey, Kathleen E.
通讯作者：
Corey, Kathleen E.
影响因子：
29.4
作者：
Innes, Hamish;Buch, Stephan;Stickel, Felix
通讯作者：
Stickel, Felix