Medical applications of phytoestrogens from the Thai herb Pueraria mirifica.
Medical applications of phytoestrogens from the Thai herb Pueraria mirifica.
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DOI：
10.1007/s11684-012-0184-8
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发表时间：
2012-03-01
影响因子：
8.1
通讯作者：
Malaivijitnond, Suchinda
中科院分区：
文献类型：
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作者：
Malaivijitnond, Suchinda
Pueraria mirifica Airy Shaw et Suvatabandhu是泰国特有的药用植物。它已被用于泰国民间医学，其振兴素质在老年妇女和男子近一百年。事实上，已经声称P. mirifica含有活性植物雌激素（具有雌激素样活性的植物物质）。利用高效液相色谱法，至少有17种植物雌激素，主要是异黄酮，已被分离。因此，迄今为止，已经进行了相当多的科学研究，包括体外细胞系研究和各种动物（包括人类）体内研究，以解决其对生殖器官、骨骼、心血管疾病和其他更年期相关症状的雌激素活性。抗氧化能力和对肿瘤细胞系的抗增殖作用也进行了评估。一般而言，奇异拟青霉可用于预防或治疗绝经期妇女以及男性更年期患者中与雌激素缺乏相关的症状。然而，在使用前需要计算每种期望效果的最佳剂量和避免不期望的副作用的平衡。
Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.