Evaluation of global and regional right ventricular systolic function in patients with pulmonary hypertension using a novel speckle tracking method
Evaluation of global and regional right ventricular systolic function in patients with pulmonary hypertension using a novel speckle tracking method
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DOI：
10.1016/j.amjcard.2006.03.056
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Zoghbi, William A.
中科院分区：
文献类型：
--
作者：
Pirat, Bahar;McCulloch, Marti L.;Zoghbi, William A.
本研究试图证明一种新颖的斑点追踪方法可用于评估右心室 (RV) 整体和区域收缩功能。对 58 名肺动脉高压患者（11 名男性；平均年龄 53 +/- 14 岁）和 19 名年龄匹配的对照进行了研究。通过传统手动追踪体积和射血分数以及新颖软件（Axius Velocity Vector Imaging）对心尖平面的超声心动图图像进行分析。通过速度矢量成像测定右心室游离壁和心室间隔的基部、中部和心尖部的心肌速度、应变率和应变。在所有受试者中，通过手动追踪获得的 RV 体积和射血分数与通过速度矢量成像方法获得的相同指数密切相关（r = 0.95 至 0.98，所有受试者的 p < 0.001）。与对照组相比，肺动脉高压患者的心肌收缩峰值速度、应变率和应变显着受损，并且在最严重的肺动脉高压患者中变化最大（全部 p < 0.05）。肺动脉收缩压和肺血管阻力多普勒指数是 RV 应变的独立预测因子（分别为 r = -0.61 和 r = -0.65，两者的 p < 0.05）。总之，新的自动化速度矢量成像方法提供了全局和区域 RV 函数的同步定量，该函数与角度无关，并且可以回顾性地应用于已存储的数字图像。 (c) 2006 爱思唯尔公司
This study sought to demonstrate that a novel speckle-tracking method can be used to assess right ventricular (RV) global and regional systolic function. Fifty-eight patients with pulmonary arterial hypertension (11 men; mean age 53 +/- 14 years) and 19 age-matched controls were studied. Echocardiographic images in apical planes were analyzed by, conventional manual tracing for volumes and ejection fractions and by novel software (Axius Velocity Vector Imaging). Myocardial velocity, strain rate, and strain were determined at the basal, mid, and apical segments of the RV free wall and ventricular septum by Velocity Vector Imaging. RV volumes and ejection fractions obtained with manual tracing correlated strongly with the same indexes obtained by the Velocity Vector Imaging method in all subjects (r = 0.95 to 0.98, p < 0.001 for all). Peak systolic myocardial velocities, strain rate, and strain were significantly impaired in patients with pulmonary arterial hypertension compared with controls and were most altered in patients with the most severe pulmonary arterial hypertension (p < 0.05 for all). Pulmonary artery systolic pressure and a Doppler index of pulmonary vascular resistance were independent predictors of RV strain (r = -0.61 and r = -0.65, respectively, p < 0.05 for both). In conclusion, the new automated Velocity Vector Imaging method provides simultaneous quantitation of global and regional RV function that is angle independent and can be applied retrospectively to already stored digital images. (c) 2006 Elsevier Inc.