The effect of elevations in internal temperature on event-related potentials during a simple cognitive task in humans
The effect of elevations in internal temperature on event-related potentials during a simple cognitive task in humans
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DOI：
10.1152/ajpregu.00086.2016
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发表时间：
2016-07-01
影响因子：
2.8
通讯作者：
Nakata, Hiroki
中科院分区：
文献类型：
--
作者：
Shibasaki, Manabu;Namba, Mari;Nakata, Hiroki
高温对认知功能的影响仍然是模棱两可的，也许是因为方法上的差异。使用脑电图事件相关电位（ERP），我们测试的假设，被动热应激损害认知加工。13名志愿者在两种热条件下，常温时间控制和热应激，在不同的日子重复听觉oddball范式。对于热应力试验，这些范例在预热应力下进行（即，正常体温）基线时，当食管温度增加了类似于0.8 ℃时，当食管温度增加了类似于2.0 ℃时，以及在热应激后的冷却期间。记录每节反应时和ERP。在时间控制试验中，受试者在与热应激试验大致相同的时间间隔内进行听觉古怪范式。听觉处理的指标（N100）的峰值潜伏期和振幅没有改变，无论热条件。刺激分类/评估时间的指标（P300的潜伏期）和反应时间在热应激期间缩短;此外，认知处理的指标（P300的振幅）在严重热应激期间（8.3 ± 1.3 μ V）相对于基线（12.2 ± 1.0 μ V，P < 0.01）显著降低。在时间控制试验期间，这些指标均无变化。在随后的全身降温过程中，P300的波幅仍在降低，反应时和潜伏期仍在缩短。这些结果表明，过度升高的内部温度降低认知处理，但促进分类时间。
The effect of hyperthermia on cognitive function remains equivocal, perhaps because of methodological discrepancy. Using electroencephalographic event-related potentials (ERPs), we tested the hypothesis that a passive heat stress impairs cognitive processing. Thirteen volunteers performed repeated auditory oddball paradigms under two thermal conditions, normothermic time control and heat stress, on different days. For the heat stress trial, these paradigms were performed at preheat stress (i.e., normothermic) baseline, when esophageal temperature had increased by similar to 0.8 degrees C, when esophageal temperature had increased by similar to 2.0 degrees C, and during cooling following the heat stress. The reaction time and ERPs were recorded in each session. For the time control trial, subjects performed the auditory oddball paradigms at approximately the same time interval as they did in the heat stress trial. The peak latency and amplitude of an indicator of auditory processing (N100) were not altered regardless of thermal conditions. An indicator of stimulus classification/evaluation time (latency of P300) and the reaction time were shortened during heat stress; moreover an indicator of cognitive processing (the amplitude of P300) was significantly reduced during severe heat stress (8.3 +/- 1.3 mu V) relative to the baseline (12.2 +/- 1.0 mu V, P < 0.01). No changes in these indexes occurred during the time control trial. During subsequent whole body cooling, the amplitude of P300 remained reduced, and the reaction time and latency of P300 remained shortened. These results suggest that excessive elevations in internal temperature reduce cognitive processing but promote classification time.