Transient uptake of serotonin by newborn olfactory projection neurons
Transient uptake of serotonin by newborn olfactory projection neurons
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DOI：
10.1073/pnas.231471298
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发表时间：
2001-10-23
影响因子：
11.1
通讯作者：
Sullivan, JM
中科院分区：
文献类型：
--
作者：
Beltz, BS;Benton, JL;Sullivan, JM
在脊椎动物和无脊椎动物的嗅觉通路中，已经记录了感觉和神经元间群体的终生周转，从而产生了新的传入和神经元间群体的轴突必须插入高度专门化的肾小球神经元的情况。这些神经元突触所在的初级嗅觉处理区的密集的神经元能神经支配也是跨物种的一致特征。先前对龙虾的研究表明，血清素促进嗅觉投射神经元的分支。本文提出的证据表明，5-羟色胺也调节龙虾投射神经元的增殖和存活，以及神经元的作用与新生神经元对5-羟色胺的瞬时摄取有关。
A life-long turnover of sensory and interneuronal populations has been documented in the olfactory pathways of both vertebrates and invertebrates, creating a situation where the axons of new afferent and interneuronal populations must insert into a highly specialized glomerular neuropil. A dense serotonergic innervation of the primary olfactory processing areas where these neurons synapse also is a consistent feature across species. Prior studies in lobsters have shown that serotonin promotes the branching of olfactory projection neurons. This paper presents evidence that serotonin also regulates the proliferation and survival of projection neurons in lobsters, and that the serotonergic effects are associated with a transient uptake of serotonin into newborn neurons.