Postoperative Hypoalbuminemia Is Associated With Outcome in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
Postoperative Hypoalbuminemia Is Associated With Outcome in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
复制标题
DOI：
10.1053/j.jvca.2010.09.008
复制
发表时间：
2011-06-01
影响因子：
2.8
通讯作者：
Choi, In-Cheol
中科院分区：
文献类型：
--
作者：
Lee, Eun-Ho;Chin, Ji-Hyun;Choi, In-Cheol
目的：探讨非体外循环冠状动脉旁路移植术(OPCAB)术后即刻低蛋白血症与预后的关系。设计：回顾性分析医学资料。地点：心脏手术室和成人心血管重症监护病房。参与者：690例成人患者在30个月的时间内接受择期OPCAB手术。干预：无。测量和主要结果：为了评估术后即刻低蛋白血症的临床相关性，记录了术后12小时内的最低血清白蛋白水平。通过受试者操作特征图中曲线下的面积计算包括死亡在内的30天不良事件的截断点。根据截断值对患者进行分类，并使用倾向分数匹配分析比较不同组之间的结果。采用多因素分析研究术后即刻低蛋白血症对OPCAB结局的影响。术后即刻白蛋白浓度预测30天不良事件的临界值为2.3g/dL。术后即刻低蛋白血症(
Objective: The authors aimed to investigate whether immediate postoperative hypoalbuminemia could be associated with outcomes after off-pump coronary artery bypass graft (OPCAB) surgery.Design: A retrospective analysis of the medical data.Setting: Cardiac operating room and adult cardiovascular intensive care unit at a single institution.Participants: Six hundred ninety adult patients underwent elective OPCAB surgery over a 30-month period.Interventions: None.Measurements and Main Results: To evaluate the clinical relevance of immediate postoperative hypoalbuminemia, the lowest serum albumin level measured over the first 12 hours postoperatively was recorded. A cutoff point was calculated by the area under the curve in the receiver operating characteristic plot for 30-day adverse events including death. Patients were classified according to the cutoff value, and outcomes were compared between groups using propensity score matching analysis. The impact of immediate postoperative hypoalbuminemia on OPCAB outcome was investigated using multivariate analysis. The cutoff value for immediate postoperative albumin concentration for predicting 30-day adverse events was 2.3 g/dL. Immediate postoperative hypoalbuminemia (