Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat
Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat
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DOI：
10.1016/s0014-2999(99)00156-9
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发表时间：
1999-04-09
影响因子：
5
通讯作者：
Koch, M
中科院分区：
文献类型：
--
作者：
Fendt, M;Koch, M
惊厥反应是评估药物对哺乳动物中枢神经系统感觉运动信息处理影响的一个有用的行为模型。预脉冲抑制大鼠的声学惊吓反应是感觉运动门控机制的一种可操作性措施，这可能是注意和反应选择所必需的。桥脑尾侧网状核是介导声惊厥反应的关键成分，并接受抑制性胆碱能投射，这可能是脉冲前抑制的重要因素。本研究测试了微量注射M胆碱/烟碱型乙酰胆碱受体激动剂卡巴胆碱和M胆碱型乙酰胆碱受体拮抗剂东莨菪碱是否调制了对听性惊厥的预脉冲抑制。卡巴胆碱(0-40nmol/0.5mU L)剂量依赖地减弱惊厥，增强脉冲前抑制。东莨菪碱(0-40nmo1/0.5mU L)在10nmo1剂量下呈剂量依赖性地增强惊厥，降低脉冲前抑制。东莨菪碱(40nmol)也能增加大鼠的自发运动活动。这些发现支持脑桥尾侧网状核乙酰胆碱受体抑制声惊厥反应的假说，并参与了脉冲前惊厥抑制的中介作用。(C)1999 Elsevier Science B.V.保留所有权利。
The startle response is a useful behavioural model to assess drug effects on sensorimotor information processing in the mammalian central nervous system. Prepulse inhibition of the acoustic startle response in rats is an operational measure for sensorimotor gating mechanisms which may be necessary for attention and response selection. The caudal pontine reticular nucleus is a key element of the pathway that mediates the acoustic startle response and receives an inhibitory cholinergic projection that might be important for prepulse inhibition. The present study tested whether prepulse inhibition of acoustic startle is modulated by microinfusions of the muscarinic/nicotinic acetylcholine receptor agonist carbachol and of the muscarinic acetylcholine receptor antagonist scopolamine. Carbachol (0-40 nmol/0.5 mu l) dose dependently attenuated startle and enhanced prepulse inhibition. Scopolamine (0-40 nmol/0.5 mu l) dose-dependently enhanced startle and reduced prepulse inhibition at a dose of 10 nmol. Scopolamine (40 nmol) also increased the spontaneous motor activity of the rats. These findings lend support to the hypothesis that muscarinic acetylcholine receptors in the caudal pontine reticular nucleus inhibit the acoustic startle response and are involved in the mediation of prepulse inhibition of startle. (C) 1999 Elsevier Science B.V. All rights reserved.