Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section.
Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section.
复制标题
窦和主动脉神经切断后仔猪呼吸暂停时间延长，存活率受损。
DOI：
10.1152/jappl.1990.68.3.1048
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Haddad,GG
中科院分区：
文献类型：
--
作者：
Donnelly,DF;Haddad,GG
我们研究了颈动脉体去神经（CX，n = 9）、CX +主动脉神经切断（CAX，n = 9）和假手术（SHAM，n = 7）对幼龄仔猪（小于9天）心肺和代谢功能的影响。为了比较，还研究了1月龄猪。手术后1天进行研究，在此期间，在常氧条件下记录通气（气压体积描记法）、心率、血压、动脉血气和脑电图。与假手术仔猪（动脉PCO 2 = 36.4 +/- 1.5 Torr）相比，CX和CAX仔猪通气不足（动脉PCO 2分别= 47.1 +/- 2.6和45.4 +/- 3.1 Torr）。CX仔猪的平均呼吸暂停为8.0 +/- 3.0/h，平均持续时间为26 +/- 3 s。CAX仔猪平均呼吸暂停17.2 +/- 7.9/h，持续30 +/- 5 s。在假手术动物中从未观察到如此长的呼吸暂停。去神经仔猪的平均心率和血压与SHAM仔猪的平均心率和血压无显著差异。在研究后随访的动物中，尽管环境和饲料条件相同（P <0.05;卡方2），但在手术后7天，在CX（9只中的5只）和CAX（9只中的6只）仔猪中观察到显著高的死亡率，而在假手术动物中未观察到（7只中的0只）。一个月大的去神经动物表现出周期性呼吸和换气不足，但没有死亡。这些结果表明，在新生仔猪中，1）外周化学感受器在维持正常通气和避免长时间呼吸暂停方面具有积极作用，2）生命早期的存活率严重依赖于外周化学感受器。
We examined the effects of carotid body denervation (CX, n = 9), CX + aortic nerve section (CAX, n = 9), and sham surgery (SHAM, n = 7) on cardiorespiratory and metabolic function in young piglets (less than 9 days). For comparison, 1-mo-old pigs were also studied. Studies were performed 1 day after surgery, during which time ventilation (barometric plethysmography), heart rate, blood pressure, arterial blood gases, and electroencephalogram were recorded under normoxia. CX and CAX piglets hypoventilated (arterial PCO2 = 47.1 +/- 2.6 and 45.4 +/- 3.1 Torr, respectively) compared with SHAM piglets (arterial PCO2 = 36.4 +/- 1.5 Torr). CX piglets had an average of 8.0 +/- 3.0 apneas/h, lasting, on average, 26 +/- 3 s. CAX piglets averaged 17.2 +/- 7.9 apneas/h, lasting 30 +/- 5 s. Such long apneas were never observed in SHAM animals. Mean heart rate and blood pressure in denervated piglets were not significantly different from those in SHAM piglets. In animals followed up poststudy, significantly high mortality was observed in CX (5 of 9) and CAX (6 of 9) piglets by 7 days after surgery but not in SHAM animals (0 of 7) despite identical environmental and feed conditions (P less than 0.05; chi 2). One-month-old denervated animals showed periodic breathing and hypoventilation, but none died. These results suggest that in the newborn piglet 1) peripheral chemoreceptors have an active role in maintaining normal ventilation and avoidance of prolonged apnea and 2) survivability in early life is critically dependent on peripheral chemoreceptors.