Evaluation of CyberKnife frameless real-time image-guided stereotactic radiosurgery for spinal lesions
Evaluation of CyberKnife frameless real-time image-guided stereotactic radiosurgery for spinal lesions
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DOI：
10.1159/000075109
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发表时间：
2003-01-01
影响因子：
1.7
通讯作者：
Welch, WC
中科院分区：
文献类型：
--
作者：
Gerszten, PC;Ozhasoglu, C;Welch, WC
背景：本研究评价了CyberKnife无框架图像引导放射外科系统治疗脊柱病变的效果。研究方法：该系统利用一对正交的X射线相机与动态操纵的机器人安装的直线加速器的耦合，该直线加速器将治疗束引导到预期目标，而不使用基于框架的固定。相对于颅骨标志定位和跟踪颈椎病变;相对于基准标记跟踪下脊柱病变。采用单次放射外科技术治疗了115名连续患者的125处脊柱病变。结果：肿瘤体积为0.3 ~ 232 ml，平均27.8 ml。肿瘤放射剂量维持在12-20戈伊至80%等剂量线（平均14戈伊）;脊髓或椎管接受大于8戈伊的体积范围为0.0 - 1.7 ml（平均0.2 ml）。在随访期间（3-24个月），未发生急性放射毒性或新的神经功能缺损。结论：射波刀系统是可行的，安全和有效的。脊柱病变放射外科消融的主要潜在受益是门诊治疗时间短，恢复快，反应好。版权所有（C）2003 S. Karger AG，巴塞尔。
Background: This study evaluated the CyberKnife frameless image-guided radiosurgery system for the treatment of spinal lesions. Methods: This system utilizes the coupling of an orthogonal pair of X-ray cameras to a dynamically manipulated robot-mounted linear accelerator that guides the therapy beam to the intended target without the use of frame-based fixation. Cervical spine lesions are located and tracked relative to skull bony landmarks; lower spinal lesions are tracked relative to fiducial markers. 125 spinal lesions in 115 consecutive patients were treated with a single-fraction radiosurgery technique. Results: Tumor volume ranged from 0.3 to 232 ml (mean 27.8 ml). Tumor radiation dose was maintained at 12-20 Gy to the 80% isodose line (mean 14 Gy); the spinal cord or canal volume receiving greater than 8 Gy ranged from 0.0 to 1.7 ml (mean 0.2 ml). No acute radiation toxicity or new neurological deficits occurred during the follow-up period (3-24 months). Conclusions: The CyberKnife system was found to be feasible, safe and effective. The major potential benefits of radiosurgical ablation of spinal lesions are short treatment time in an outpatient setting with rapid recovery and good response. Copyright (C) 2003 S. Karger AG, Basel.