ORGANIZATION OF VESTIBULAR INPUTS TO NUCLEUS-TRACTUS-SOLITARIUS AND ADJACENT STRUCTURES IN CAT BRAIN-STEM
ORGANIZATION OF VESTIBULAR INPUTS TO NUCLEUS-TRACTUS-SOLITARIUS AND ADJACENT STRUCTURES IN CAT BRAIN-STEM
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DOI：
10.1152/ajpregu.1994.267.4.r974
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发表时间：
1994-10-01
影响因子：
2.8
通讯作者：
MILLER, AD
中科院分区：
文献类型：
--
作者：
YATES, BJ;GRELOT, L;MILLER, AD
前庭系统在姿势改变时维持稳定的血压和呼吸，对于引起晕动病相关的呕吐是必不可少的。由于孤束核(NTS)参与交感和吸气流出的调节以及呕吐的触发，我们验证了猫该区域接受前庭输入的假说。在一组实验中，将示踪剂菜豆亮氨酸凝集素微量注射到前庭内侧和下部核团，标记为投射到NTS的中部和外侧区域。在电生理实验中，电刺激前庭神经改变了位于相同区域的神经元的放电频率。一些具有前庭输入的神经元收到来自腹部迷走神经的会聚信号，并可能潜在地介导与晕动病相关的呕吐。另一些则接受会聚的压力感受器输入，并可作为前庭交感反射某些成分的底物。相比之下，背侧呼吸组的吸气神经元接受的前庭输入很少，这表明前庭-呼吸反射是由位于其他地方的细胞调节的。
The vestibular system is involved in maintaining stable blood pressure and respiration during changes in posture and is essential for eliciting motion sickness-related vomiting. Because the nucleus tractus solitarius (NTS) participates in the regulation of sympathetic and inspiratory outflow and the triggering of emesis, we tested the hypothesis that this region receives vestibular inputs in cats. In one set of experiments, microinjections of the tracer Phaseolus vulgaris leucoagglutinin into the medial and inferior vestibular nuclei labeled projections to the middle and lateral regions of the NTS. In electrophysiological experiments, electrical stimulation of the vestibular nerve modified the firing rates of neurons located in the same regions. Some neurons with vestibular inputs received convergent signals from the abdominal vagus nerve and could potentially mediate motion sickness-related vomiting. Others received convergent baroreceptor inputs and could act as a substrate for some components of vestibulosympathetic reflexes. In contrast, inspiratory neurons in the dorsal respiratory group received little vestibular input, suggesting that vestibulorespiratory reflexes are mediated by cells located elsewhere.