The Contribution of Previous Information to Current Memory Processing: Comparisons Between Older Adults with Mild Cognitive Impairment andNormal Elderly
The Contribution of Previous Information to Current Memory Processing: Comparisons Between Older Adults with Mild Cognitive Impairment andNormal Elderly
复制标题
先前信息对当前记忆处理的贡献：轻度认知障碍老年人与正常老年人的比较
DOI：
10.1007/978-981-16-6324-6_16
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Juan Li
中科院分区：
文献类型：
--
作者：
Bei Liu;Chiyin Zheng;Pengyun Wang;Jing Yu;Rui Li;Wendong Xiao;Juan Li
大量的研究发现，先前信息会影响当前外显工作记忆的加工。然而，关于前一个事件对内隐工作记忆加工的影响的研究还很有限。本研究在健康老年人和轻度认知障碍（MCI）患者中调查了这一问题。采用混合延迟匹配任务考察了内隐工作记忆的加工过程，不考虑外显记忆成分。收集功能性磁共振成像数据。行为实验结果表明，先前研究的信息能够促进随后的内隐工作记忆加工。然而，这种影响在MCI患者中受损，尽管健康的老年人和MCI患者都表现出显着的内隐工作记忆处理。全脑激活分析显示，在左侧楔叶中，组与先前信息（已研究和未研究）之间存在显著的相互作用。心理生理交互作用分析表明，健康老年人左侧楔前叶与双侧枕中回及左侧楔前叶背侧区的功能连接受到先前情景信息的调制。而MCI患者中未发现明显区域。本研究首次揭示了健康老年人先前情景信息对后续内隐工作记忆加工的促进作用，并揭示了先前情景信息与当前内隐工作记忆加工相互作用的关键皮层结构和皮层通路。
Numerous studies have found that previous information can affect the current explicit working memory processing. However, the study that investigate the effect of previous episodes on the implicit working memory processing has been limited. The present study investigated this issue in healthy older adults and patients with mild cognitive impairment (MCI). A hybrid delayed-match-to-sample task was used to examine the implicit working memory processing regardless of explicit memory components. Functional magnetic resonance imaging data was collected. The behavioral results demonstrated that the previously studied information was able to facilitate the following implicit working memory processing. Nevertheless, this effect was impaired in MCI patients, although both healthy older adults and MCI patients have shown significant implicit working memory processing. Whole-brain activation analysis revealed that there were significant interactions between group and previous information (Studied and Non-studied) in the left cuneus. The psychophysiological-interaction analysis showed that the functional connectivity between left cuneus and regions in bilateral middle occipital gyrus as well as dorsal regions of left precuneus was modulated by previous episodic information in healthy older adults. However, no significant region was found in MCI patients. The current study for the first time revealed that the previous episodic information can facilitate the following implicit working memory procession in healthy older adults, and demonstrated the key cortical structure and cortical pathways underlying the interactions between previous episodic information and current implicit working memory processing.