Ethyl glucuronide in keratinous matrices as biomarker of alcohol use: A correlation study between hair and nails
Ethyl glucuronide in keratinous matrices as biomarker of alcohol use: A correlation study between hair and nails
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DOI：
10.1016/j.forsciint.2017.08.022
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发表时间：
2017-10-01
影响因子：
2.2
通讯作者：
van Nuijs, Alexander L. N.
中科院分区：
文献类型：
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作者：
Cappelle, Delphine;Neels, Hugo;van Nuijs, Alexander L. N.
为了量化酒精使用，客观，特异和敏感的长期酒精标志物是必要的。乙基葡萄糖醛酸苷（EtG）是酒精的直接代谢产物，在头发和指甲等角质基质中积累，是检测慢性饮酒的特异性和敏感性长期生物标志物。到目前为止，研究主要集中在头发中EtG的检测，而指甲中EtG的测量研究很少。在这篇文章中，我们评估了来自相同个体的头发，手指和脚趾甲中的EtG浓度，以评估基质之间的直接相关性。为此，从比利时两个精神病中心接受酒精使用障碍治疗的患者中收集了总计45根头发，41个指甲和13个脚趾甲样本。采用气相色谱-串联质谱法对样品进行分析。头发中的EtG浓度范围为
To quantify alcohol use, objective, specific and sensitive long-term alcohol markers are necessary. Ethyl glucuronide (EtG), a direct metabolite of alcohol, accumulates in keratinous matrices such as hair and nails, and is a specific and sensitive long-term biomarker for the detection of chronic alcohol consumption. So far, research has primarily focused on the detection of EtG in hair, and studies on its measurement in nails are scarce. In this article, we assessed EtG concentrations in hair, finger-and toenails from the same individuals in order to evaluate the direct correlation between the matrices. To this end, a total amount of 45 hair, 41 fingernail, and 13 toenail samples were collected from patients treated for alcohol use disorders at two psychiatric centers in Belgium. Samples were analyzed by gas chromatography-tandem mass spectrometry. Hair EtG concentrations ranged from