Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlA in Pseudomonas aeruginosa.
Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlA in Pseudomonas aeruginosa.
复制标题
鱼腥草素钠体外抑制铜绿假单胞菌生物膜分散和 bdlA 表达。
DOI：
10.1007/s11033-018-4497-9
复制
发表时间：
2018
影响因子：
2.8
通讯作者：
Wu Daqiang
中科院分区：
文献类型：
--
作者：
Wang Tianming;Huang Weifeng;Duan Qiangjun;Wang Jian;Cheng Huijuan;Shao Jing;Li Fang;Wu Daqiang
生物膜分散是生物膜发展的最后一步，它允许细菌在新的地点繁殖新的生物膜。在以往的研究中，我们发现鱼腥草素钠(SH)能有效抑制铜绿假单胞菌的生物被膜形成和运动。在这里，我们研究了SH对生物膜分散体OFP的影响。铜绿假单胞菌的体外模型。结果表明，植物衍生物SH能有效地抑制两种生物膜的扩散。铜绿假单胞菌和关键生物膜调节因子BdlA的基因和蛋白表达呈剂量依赖关系。此外，我们的研究结果表明，SH可以渗透到生物膜OFP中。铜绿假单胞菌抑制生物膜的生命周期。因此，这些结果表明SH的抗菌活性可能部分归因于其破坏INP生物膜分散的能力。铜绿假单胞菌。
Biofilm dispersion is the last step in the development of biofilms, and allows bacteria to spawn novel biofilms in new locales. In the previous studies, we found that sodium houttuyfonate (SH) is effective at inhibiting biofilm formation and motility ofPseudomonas aeruginosa. Here, we investigated the effect of SH against the biofilm dispersion ofP. aeruginosaby an in vitro model. The results show that the plant derivative, SH, could effectively inhibit both biofilm dispersion ofP. aeruginosa, and gene and protein expression of the key biofilm regulator BdlA in a dose-dependent manner. Furthermore, our presented results suggest that SH can penetrate into the biofilm ofP. aeruginosato repress the biofilm life cycle. Therefore, these results indicate that the antimicrobial activity of SH may be partially due to its ability to disrupt biofilm dispersion inP. aeruginosa.