New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis.
New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis.
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DOI：
10.1007/s11926-014-0429-4
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发表时间：
2014-07
影响因子：
5
通讯作者：
Lundberg, Ingrid E.
中科院分区：
文献类型：
--
作者：
Munters, Li Alemo;Alexanderson, Helene;Crofford, Leslie J.;Lundberg, Ingrid E.
关键词：
在推荐的治疗下，大多数特发性炎症性肌病（IIM）患者会出现肌肉损伤和健康状况不佳。据报道，运动对慢性多发性肌炎和皮肌炎的肌肉性能、有氧能力和健康有有益影响，在一定程度上对活动性疾病和包络体肌炎（IBM）也有有益影响。重要的是，随机对照试验（RCTs）表明，改善健康和降低临床疾病活动性可以通过增加有氧能力来调节。最近，关于运动对骨骼肌潜在影响机制的报道表明，运动增加了有氧能力（即增加了线粒体容量和毛细血管密度，降低了乳酸水平），激活了有氧表型和肌肉生长程序中的基因，并下调了与炎症相关的基因。总之，运动有助于全身和肌肉内的适应，这表明运动是改善IIM肌肉表现和健康的基础。有必要通过随机对照试验来研究运动对活动性疾病和IBM的影响。
With recommended treatment, a majority with idiopathic inflammatory myopathy (IIM) develop muscle impairment and poor health. Beneficial effects of exercise have been reported on muscle performance, aerobic capacity and health in chronic polymyositis and dermatomyositis and to some extent in active disease and inclusion body myositis (IBM). Importantly, randomized controlled trials (RCTs) indicate that improved health and decreased clinical disease activity could be mediated through increased aerobic capacity. Recently, reports seeking mechanisms underlying effects of exercise in skeletal muscle indicate increased aerobic capacity (i.e. increased mitochondrial capacity and capillary density, reduced lactate levels), activation of genes in aerobic phenotype and muscle growth programs, and down regulation in genes related to inflammation. Altogether, exercise contributes to both systemic and within-muscle adaptations demonstrating that exercise is fundamental to improve muscle performance and health in IIM. There is a need for RCTs to study effects of exercise in active disease and IBM.
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影响因子：
14.5
作者：
Cea, G;Bendahan, D;Taylor, DJ
通讯作者：
Taylor, DJ
DOI：
10.1046/j.1365-201x.2001.00822.x
发表时间：
2001-03-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Lundberg, IE
通讯作者：
Lundberg, IE
影响因子：
5.5
作者：
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通讯作者：
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影响因子：
5.5
作者：
Isenberg, DA;Allen, E;Miller, F
通讯作者：
Miller, F
影响因子：
5.5
作者：
Chung, YL;Wassif, WS;Scott, DL
通讯作者：
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