Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
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DOI：
10.1111/j.1574-6968.1999.tb13737.x
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发表时间：
1999-08-15
影响因子：
2.1
通讯作者：
Kashiwabara, Y
中科院分区：
文献类型：
--
作者：
Kai, M;Matsuoka, M;Kashiwabara, Y
对6株二氨基二苯砜耐药麻风分枝杆菌DHPS基因的核苷酸序列分析表明，DHPS基因的突变局限于高度保守的第53或55位氨基酸残基。虽然在其他细菌中已经报道了55位氨基酸残基或其同源位点的突变，但在细菌中第53位氨基酸残基的突变是第一例。这是第一篇将DHPS突变与M的磺胺耐药联系起来的论文。麻风病人这一发现具有医学和社会意义，因为麻风病在某些地区仍然是一个大问题。(C)1999年，欧洲微生物学会联合会。由Elsevier Science B.V.出版，版权所有。
The nucleo tide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.