Health-related quality of life trajectories among adults with tuberculosis - Differences between latent and active infection
Health-related quality of life trajectories among adults with tuberculosis - Differences between latent and active infection
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DOI：
10.1378/chest.07-1494
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发表时间：
2008-02-01
期刊：
影响因子：
9.6
通讯作者：
Fitzgerald, J. Mark
中科院分区：
文献类型：
--
作者：
Marra, Carlo A.;Marra, Fawziah;Fitzgerald, J. Mark
背景：结核病 (TB) 仍然是一个公共卫生威胁，每年对发病率和死亡率都有重大影响。然而，很少有研究探讨活动性和潜伏性结核感染 (LTBI) 对健康相关生活质量 (HRQL) 的影响。方法：对最近诊断的活动性结核或 LTBI 患者在基线、3 个月和 6 个月时进行简表 36 (SF-36) 和 Beek 抑郁量表 (DI)。在调整潜在的混杂因素后，使用混合效应线性回归来比较两个患者组的 HRQL 随时间变化的轨迹。使用序数逻辑回归来确定 HRQL 变化之间至少具有最小重要差异的关系。结果：104 名活动性结核病患者和 102 名 LTBI 患者参与。在基线时，与 LBTI 参与者相比，活动性结核病参与者的 SF-36 平均域和组成部分得分显着较低（低 4 至 12 分，p < 0.03），平均 Beck DI 得分较高（高 4 分，p < 0.0001）。在应答者分析中，活动性结核病患者在 6 个月时报告的评分改善至少具有最小的活力差异（比值比 [OR]，2.7；95% 置信区间（OR，1.3 至 5.6）、角色身体评分（OR，3.1；95% CI；1.4 至 6.5）、精神成分评分（OR，3.2；95% CI，1.5 至 6.5）。 6.9）、社会功能（OR，11.1；95% CI，3.8 至 33）和角色情绪（OR，2.7；95% CI，1.2 至 6.0）。 结论：6 个月后，活动性结核病患者在大多数 HRQL 领域都有很大改善，然而，与 LTBI 参与者和美国常模相比，治疗完成时 HRQL 仍然较低。
Background: Tuberculosis (TB) remains a public health threat with significant annual impacts on morbidity, and mortality. However, few studies have examined the impact of active and latent TB infection (LTBI) on health-related quality of life (HRQL).Methods: Patients with recently diagnosed active TB or LTBI patients were administered the Short Form-36 (SF-36) and the Beek depression inventory (DI) at baseline, 3 months, and 6 months. Mixed-effect linear regression was used to compare the trajectory of HRQL over time in the two patient groups after adjusting for potential confounders. Ordinal logistic regression was used to determine the relationship between changes in HRQL of at least the minimal important difference.Results: One hundred four active TB and 102 LTBI patients participated. At baseline, participants with active,TB had significantly lower SF-36 mean domain and component scores (4 to 12 points lower, p < 0.03) and higher mean Beck DI scores (4 points higher, p < 0.0001) when compared to LBTI participants. In the responder analysis, those with active TB were associated with reporting improved scores at 6 months of at least the minimal important difference in vitality (odds ratio [OR], 2.7; 95% confidence interval (OR, 1.3 to 5.6), role physical (OR, 3.1; 95% CI; 1.4 to 6.5), mental component score (OR, 3.2; 95% CI, 1.5 to 6.9), social functioning (OR, 11.1; 95% CI, 3.8 to 33), and role emotional (OR, 2.7; 95% CI, 1.2 to 6.0).Conclusions: Active TB patients had large improvements in most HRQL domains by 6 months. However, when compared to LTBI participants and US norms, HRQL was still low at completion of therapy.