Effects of granisetron and its combination with dexamethasone on cisplatin-induced delayed emesis in the ferret
Effects of granisetron and its combination with dexamethasone on cisplatin-induced delayed emesis in the ferret
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DOI：
10.1016/s0306-3623(98)00102-5
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Minami, M
中科院分区：
文献类型：
--
作者：
Fukunaka, N;Sagae, S;Minami, M
1.利用雪貂研究格拉司琼及其与地塞米松联合治疗顺铂（CDDP）给药后延迟性呕吐的效果。2．格拉司琼组和格拉司琼与地塞米松联合组在急性期和延迟期的呕吐总量、首次呕吐潜伏期和呕吐持续时间均显着抑制CDDP引起的呕吐。3．与CDDP对照组相比，联合组雪貂的食物和水消耗显着增加。4．给予CDDP 3天后，雪貂回肠中5-羟色胺（5-HT）水平增加，尾部区域5-羟基吲哚乙酸（5-HIAA）水平增加。提示格拉司琼和/或地塞米松的止吐作用与延迟性呕吐中5-HT水平无关。5．格拉司琼及其与地塞米松的联合治疗对于CDDP引起的呕吐均有效，但对于延迟期呕吐持续时间，联合治疗比单独使用格拉司琼更有效。 (C) 1998 爱思唯尔科学公司。
1. Granisetron and its combination with dexamethasone for the treatment of delayed emesis following cisplatin (CDDP) administration were investigated using ferrets.2. CDDP-induced emesis was significantly inhibited in both the granisetron group and the combined granisetron and dexamethasone group during the acute and delayed phase in terms of total emesis, latency to first emesis and duration of emesis.3. Food and water consumption in the combined group of ferrets was significantly increased as compared with the CDDP control group.4. 5-Hydroxytryptamine (5-HT) level was increased in the ileum and the 5-hydroxyindole acetic acid (5-HIAA) level was increased in the area postrema of ferrets after 3 days of CDDP administration. It is suggested that the antiemetic activity of granisetron and/or dexamethasone is not related to 5-HT levels in delayed emesis.5. Both granisetron and its combination with dexamethasone are effective in CDDP-induced emesis, but combination treatment is more effective than granisetron alone for the duration of emesis in the delayed phase. (C) 1998 Elsevier Science Inc.