Evidence-based recommendations for antibiotic usage to treat endodontic infections and pain A systematic review of randomized controlled trials
Evidence-based recommendations for antibiotic usage to treat endodontic infections and pain A systematic review of randomized controlled trials
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DOI：
10.1016/j.adaj.2015.11.002
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发表时间：
2016-03-01
影响因子：
3.9
通讯作者：
Kulild, James C.
中科院分区：
文献类型：
--
作者：
Aminoshariae, Anita;Kulild, James C.
背景。这项调查的目的是确定基于证据的科学方法，以帮助牙科临床医生确定开抗生素治疗牙髓感染或疼痛的适应症。方法。作者在 PROSPERO 上准备并注册了协议。他们在 MEDLINE、Scopus、Cochrane Library 和 ClinicalTrials 中进行了电子检索。政府。此外，作者还手工检索了所有相关文章的参考书目、灰色文献以及随机对照临床研究的教科书。作者独立选取相关文章得出结果。研究的总体质量尚可，偏倚风险较低，但有 2 项研究存在中度偏倚风险。结论。现有的最佳临床证据表明，没有迹象表明在术前或术后开抗生素来预防牙髓感染或疼痛，除非感染扩散到全身，患者发热，或两者兼而有之。一般来说，准确的诊断加上有效的牙髓治疗将减少微生物菌群，足以促进愈合。
Background. The purpose of this investigation was to identify evidence-based scientific methodologies to aid dental clinicians in establishing the indications for prescribing antibiotics for endodontic infection or pain.Methods. The authors prepared and registered a protocol on PROSPERO. They conducted electronic searches in MEDLINE, Scopus, Cochrane Library, and ClinicalTrials. gov. In addition, the authors hand searched the bibliographies of all relevant articles, the gray literature, and textbooks for randomized controlled clinical studies. The authors independently selected the relevant articles.Results. The overall quality of the studies was fair with a low risk of bias, but 2 studies had a moderate risk of bias.Conclusions. The best available clinical evidence signals no indications for prescribing antibiotics preoperatively or postoperatively to prevent endodontic infection or pain unless the spread of infection is systemic, the patient is febrile, or both. Generally, an accurate diagnosis coupled with effective endodontic treatment will decrease microbial flora enough for healing to occur.