Role of telomerase in radiocurability (review).
Role of telomerase in radiocurability (review).
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DOI：
10.3892/or.10.2.263
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发表时间：
2003-03
期刊：
影响因子：
4.2
通讯作者：
T. Pandita;J. R. Roti Roti-J.-R.-Roti-Roti-7707447
中科院分区：
文献类型：
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作者：
T. Pandita;J. R. Roti Roti-J.-R.-Roti-Roti-7707447
端粒酶是一种核糖核蛋白复合物，通过在染色体端粒末端添加六聚体 (TTAGGG) 重复序列来延长端粒，从而补偿端粒的持续侵蚀。端粒酶活性存在于单细胞生物和生殖细胞中，预计它在无限循环和防止端粒缩短的过程中发挥作用。端粒酶活性是几种癌细胞实际上特有的一种表型表现。经电离辐射 (IR) 处理后，多种细胞类型的端粒酶活性均得到增强。端粒酶活性水平与肿瘤细胞杀伤的IR反应之间是否存在直接相关性尚待详细解决。在这篇综述中，总结了端粒酶活性的信息，作为监测肿瘤放射治疗能力的措施。由于肿瘤生长部分归因于细胞周期失调，因此对整个细胞周期中端粒酶活性的深入了解可能有助于设计治疗剂，或者用于激活细胞中的端粒酶，其表达可以克服衰老并延长有丝分裂后细胞的寿命，或者抑制端粒酶，因为端粒酶对于增殖至关重要，因此可以提供杀死肿瘤细胞的治疗优势。
Telomerase is a ribonucleoprotein complex that elongates telomeres by adding hexameric (TTAGGG) repeats to the telomeric ends of the chromosomes, thus compensating for the continued erosion of telomeres. Telomerase activity is present in unicellular organisms and germ cells, both places where it is expected to play a role in indefinite cycling and protection from shortening of the telomeres. One phenotypic manifestation that is virtually pathognomonic of several cancer cells is the telomerase activity. Telomerase activity is enhanced in several cell types after treatment with ionizing radiation (IR). Whether there is a direct correlation between the levels of telomerase activity and IR response for tumor cell kill is yet to be addressed in detail. In this review, information is summarized on telomerase activity as a measure for monitoring the radiocurability of tumors. As tumor growth is partly due to deregulated cell cycling, insights into telomerase activity through the cell cycle may prove helpful in designing therapeutic agents either for telomerase activation in cells where its expression can overcome senescence and prolong the life of post-mitotic cells, or inhibition of telomerase where it is essential for proliferation and thus can provide a therapeutic advantage to kill the tumor cells.