The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions: Application to the Synthesis of 2H-Chromenes, Coumarins, Benzofurans, and Dihydroquinolines
The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions: Application to the Synthesis of 2H-Chromenes, Coumarins, Benzofurans, and Dihydroquinolines
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DOI：
10.1021/jo902032p
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发表时间：
2009-11-20
影响因子：
3.6
通讯作者：
Banwell, Martin G.
中科院分区：
文献类型：
--
作者：
Menon, Rajeev S.;Findlay, Alison D.;Banwell, Martin G.
描述了操作简单的Au（I）催化的末端炔的分子内氢芳基化（IMHA）反应，该反应在非常温和的条件下以高产率进行。这些方法涉及低催化剂负载。温和的反应温度和短的反应时间不需要助催化剂或添加剂，并且允许由容易获得的起始原料产生许多重要的杂环基序。
Operationally simple Au(I)-catalyzed intramolecular hydroarylation (IMHA) reactions of terminal alkynes that proceed in high yield and under very mild conditions are described. These processes involve low catalyst loadings., mild reaction temperatures, and short reaction times, require no cocatalysts or additives, and allow for the generation of a number of important heterocyclic motifs from readily accessible starting materials.