White matter connectivity of human hypothalamus
White matter connectivity of human hypothalamus
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DOI：
10.1016/j.brainres.2010.11.072
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发表时间：
2011-01-31
期刊：
影响因子：
2.9
通讯作者：
De Salles, Antonio A. F.
中科院分区：
文献类型：
--
作者：
Lemaire, Jean-Jacques;Frew, Andrew J.;De Salles, Antonio A. F.
人类下丘脑的宏观外在白质连接性和内部结构仍未完全确定。我们研究了体内扩散张量成像纤维束成像是否提供了根据下丘脑区室化的系统化证据。对 14 名受试者的左右半球内的 6 个定义的下丘脑宏观区室（视前区、视上区、前腹区、前背区、外侧区和后区）进行了探测。发现了关于下丘脑宏观结构和白质连接的重要新见解；视前区、前腹区、侧区和后区与皮质紧密相连。前腹侧特别连接到前额皮质，而视前室主要连接到深部前脑。前背侧主要连接内侧丘脑和中线灰质。视前区、前腹区和侧区的半球连接有向右额叶趋势。这些发现可能有助于新的神经调节应用和对大脑连接组学的理解。由 Elsevier B.V. 出版
The macroscopic extrinsic white matter connectivity and the internal structure of the hypothalamus are still incompletely defined in humans. We investigated whether in-vivo diffusion tensor imaging tractography provides evidence of systematization according to hypothalamic compartmentalization. Six defined hypothalamic macroscopic compartments, preoptic, supraoptic, anteroventral, anterodorsal, lateral and posterior, were probed, within the right and left hemispheres of 14 subjects. Important new insights into the macroscopic structure of hypothalamus and white matter connections were found; the preoptic, anteroventral, lateral and posterior compartments are strongly connected to the cortex. The anteroventral connects particularly to the prefrontal cortex while the preoptic compartment connects mainly to the deep anterior brain. The anterodorsal connects mainly to the medial thalamus and the midline gray matter. There is a rightward frontal trend of hemispheric connectivity for the preoptic, anteroventral and lateral compartments. These findings may aid new neuromodulation applications and understanding in brain connectomics. Published by Elsevier B.V.