Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.
Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.
复制标题
模拟微重力条件下小鼠小梁骨结构形态变化的磁共振显微镜。
DOI：
10.1002/mrm.1148
复制
发表时间：
2001
影响因子：
3.3
通讯作者：
Gulani,V
中科院分区：
文献类型：
--
作者：
Gardner,JR;Hess,CP;Webb,AG;Tsika,RW;Dawson,MJ;Gulani,V
这项工作描述了使用磁共振（MR）显微镜检查胫骨骨小梁结构的变化在小鼠后肢悬挂28天后，模型模拟啮齿动物的微重力的影响。在这项涉及小鼠的首次MR研究中，3D图像分析显示，与对照组相比，后肢悬吊小鼠的表观骨体积分数、骨小梁数量和骨小梁厚度减少，表观骨小梁间距增加（P< 0.05）。这些变化与一项独立研究的光学显微镜测量结果以及对大鼠进行的实际太空飞行实验吻合良好。Magn Reson Med 45：1122-1125，2001.© 2001 Wiley利斯公司
This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and trabecular thickness were decreased, and apparent trabecular spacing increased, significantly (P< 0.05) in hindlimb‐suspended mice compared to controls. These changes agreed well with light microcopy measurements from an independent study and also with actual spaceflight experiments with rats. Magn Reson Med 45:1122–1125, 2001. © 2001 Wiley‐Liss, Inc.