Pathogenesis of HIV-associated cardiovascular complications.
Pathogenesis of HIV-associated cardiovascular complications.
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DOI：
10.1016/s1473-3099(01)00067-6
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发表时间：
2001-09-01
期刊：
影响因子：
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通讯作者：
Lipshultz, S E
中科院分区：
文献类型：
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作者：
Barbaro, G;Fisher, S D;Lipshultz, S E
在引入高效抗逆转录病毒疗法（HAART）之前发表的综述和研究跟踪了儿童和成人心脏疾病相关的HIV感染的发病率和病程。高效抗逆转录病毒疗法的采用显著改变了艾滋病毒疾病的病程，预期艾滋病毒感染者的存活率会更长，生活质量会得到改善。然而，早期数据提出了HAART与外周和冠状动脉疾病增加相关的担忧。在这篇综述中，我们讨论了艾滋病毒相关的心血管并发症的发病机制，可能有一个在HAART时代的诊断，管理和治疗这些并发症的作用。
Reviews and studies published before the introduction of highly active antiretroviral therapy (HAART) have tracked the incidence and course of HIV infection in relation to cardiac illness in both children and adults. The introduction of HAART regimens has significantly modified the course of HIV disease, with longer survival rates and improvement of life quality in HIV-infected people expected. However, early data raised concerns about HAART being associated with an increase in both peripheral and coronary arterial diseases. In this review we discuss HIV-associated cardiovascular complications focusing on pathogenetic mechanisms that could have a role in diagnosis, management, and therapy of these complications in the HAART era.