Connectivity-Based Parcellation of the Human Temporal Pole Using Diffusion Tensor Imaging
Connectivity-Based Parcellation of the Human Temporal Pole Using Diffusion Tensor Imaging
复制标题
使用扩散张量成像对人类颞极进行基于连通性的分割
DOI：
10.1093/cercor/bht196
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发表时间：
2014-12-01
期刊：
影响因子：
3.7
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Fan, Lingzhong;Wang, Jiaojian;Jiang, Tianzi
颞极(TP)是一种具有多感觉整合能力的联合皮层，参与多种高级认知功能。然而，一种公认的人类TP的分割及其连接模式尚未很好地建立。在这里，我们试图提出一种基于解剖连接的人类TP分割方案，并揭示其次区域连接模式。有3个不同的亚区具有独特的纤维通路，包括位于腹侧的背侧(TAR)、内侧(TGM)和外侧(TGL)亚区。根据连接模式，观察到听觉和视觉加工的背侧/腹侧感觉分离，以及参与嗅觉加工的内侧TGM。结合互补静息态功能连接性分析，观察了TGM与眶前叶皮质等情绪相关区域的联系，TGL与MPFC和主要默认模式网络区域的联系，以及TAR与词旁语言区的联系。据我们所知，本研究首次尝试根据人体TP的解剖连接特征对其进行分类，这可能有助于提高我们对其连接解剖学的理解，并扩展TP相关临床研究中的现有知识。
The temporal pole (TP) is an association cortex capable of multisensory integration and participates in various high-order cognitive functions. However, an accepted parcellation of the human TP and its connectivity patterns have not yet been well established. Here, we sought to present a scheme for the parcellation of human TP based on anatomical connectivity and to reveal its subregional connectivity patterns. Three distinct subregions with characteristic fiber pathways were identified, including the dorsal (TAr), the medial (TGm), and lateral (TGl) subregions, which are located ventrally. According to the connectivity patterns, a dorsal/ventral sensory segregation of auditory and visual processing and the medial TGm involved in the olfactory processing were observed. Combined with the complementary resting-state functional connectivity analysis, the connections of the TGm with the orbitofrontal cortex and other emotion-related areas, the TGl connections with the MPFC and major default mode network regions, and the TAr connections with the perisylvian language areas were observed. To the best of our knowledge, the present study represents the first attempt to parcel the human TP based on its anatomical connectivity features, which may help to improve our understanding of its connectional anatomy and to extend the available knowledge in TP-related clinical research.