Rho GTPases and activity-dependent dendrite development
Rho GTPases and activity-dependent dendrite development
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DOI：
10.1016/j.conb.2004.05.012
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发表时间：
2004-06
影响因子：
5.7
通讯作者：
L. Aelst;H. Cline
中科院分区：
文献类型：
--
作者：
L. Aelst;H. Cline
树突形态对神经元信息处理有重要影响。多种环境因素，包括神经元活动，神经营养因子家族的生长因子，和细胞外的指导分子已被证明会影响树突的大小，形状和发展。Rho GTP酶已成为这些环境信号的关键整合因子，以调节基础树突细胞骨架。
Dendritic morphology has an important influence on neuronal information processing. Multiple environmental cues, including neuronal activity, the neurotrophin family of growth factors, and extracellular guidance molecules have been shown to influence dendritic size, shape, and development. The Rho GTPases have emerged as key integrators of these environmental cues to regulate the underlying dendritic cytoskeleton.