Developmental expression of progesterone receptor isoforms in the mouse midbrain
Developmental expression of progesterone receptor isoforms in the mouse midbrain
复制标题
DOI：
10.1097/00001756-200205070-00028
复制
发表时间：
2002-05-07
期刊：
影响因子：
1.7
通讯作者：
Küppers, E
中科院分区：
文献类型：
--
作者：
Beyer, C;Damm, N;Küppers, E
黄体酮参与大脑发育过程的调节，并控制不同神经回路的功能。我们研究了孕激素受体（PR）异构体在发育和成年雄性和雌性小鼠腹侧中脑中的表达。两种受体异构体（PR-A和B）的转录本在出生前和出生后都可以检测到，但在个体发育过程中受到不同的调控。免疫印迹显示，只有全长形式（PR-B）被短暂转录成蛋白质，而截断的PR-A异构体则无法检测到蛋白质。虽然黄体酮在发育中的中枢神经系统中的确切功能尚不完全清楚，但我们的数据暗示PR信号在发育中的黑质纹状体系统中的潜在作用。神经报告13:877-880 (C) 2002 Lippincott Williams Wilkins。
Progesterone participates in the regulation of developmental processes in the brain and controls the function of distinct neural circuits. We have studied the expression of progesterone receptor (PR) isoforms in the developing and adult male and female mouse ventral midbrain. Transcripts of both receptor isoforms (PR-A and B) were detectable pre- and postnatally but regulated differentially during ontogeny Immunoblotting revealed that only the full-length form (PR-B) is transcribed transiently into protein, whereas the truncated PR-A isoform is not detectable as protein. Although the precise function of progesterone in the developing CNS is not fully understood, our data implicate a potential role for PR signaling for the developing nigrostriatal system. NeuroReport 13:877-880 (C) 2002 Lippincott Williams Wilkins.