Body mass index, change in body silhouette, and risk of asthma in the E3N cohort study
Body mass index, change in body silhouette, and risk of asthma in the E3N cohort study
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DOI：
10.1093/aje/kwg131
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发表时间：
2003-07-15
影响因子：
5
通讯作者：
Clavel-Chapelon, F
中科院分区：
文献类型：
--
作者：
Romieu, I;Avenel, V;Clavel-Chapelon, F
为了评估体重指数 (BMI)（体重 (kg)/身高 (m)(2)）和身体轮廓变化对哮喘风险的影响，作者调查了 1990 年至 1993 年间参加法国 E3N 队列研究的一组女性。作者在基线时确定了 67,229 名 40-65 岁女性中的 372 例哮喘病例。使用比例风险模型对数据进行分析，以确定与体重指数和身体轮廓相关的哮喘发病风险。报告的基线 BMI 与哮喘发病率相关，随着 BMI 五分位数的增加，风险显着增加（趋势检验：p < 0.001）。与 BMI 20-21.4（第二个五分位数）相比，调整潜在混杂因素后，BMI >= 27 的女性发生哮喘的风险增加了一倍（多变量相对风险 = 2.02，95% 置信区间：1.38、2.98）。初潮和随访研究开始之间体重的增加与哮喘风险显着相关（对于两个轮廓的增加，相对风险= 1.66，95％置信区间：1.18，2.32）。作者得出的结论是，高 BMI 与哮喘发病风险显着相关，初潮和成年期间身体轮廓的增加与晚年哮喘发病率相关。
To evaluate the impact of body mass index (BMI) (weight (kg)/height (m)(2)) and change in body silhouette on asthma risk, the authors investigated a cohort of women participating in the E3N Cohort Study in France from 1990 to 1993. The authors identified 372 incident cases of asthma among 67,229 women aged 40-65 years at baseline. Data were analyzed using proportional hazard models to determine the risk of asthma incidence in relation to BMI and body silhouette. Reported BMI at baseline was related to the incidence of asthma, with a significantly increased risk corresponding to increasing BMI quintiles (test for trend: p < 0.001). Compared with a BMI of 20-21.4 (second quintile), women with a BMI >= 27 had double the risk of incident asthma after adjustment for potentially confounding factors (multivariate relative risk = 2.02, 95% confidence interval: 1.38, 2.98). Increase in body mass between menarche and the start of the follow-up study was significantly related to asthma risk (for an increase of two silhouettes, relative risk = 1.66, 95% confidence interval: 1.18, 2.32). The authors conclude that a high BMI is significantly related to the risk of asthma incidence and that an increase in body silhouette between menarche and adulthood is related to the incidence of asthma later in life.