Genetics of common forms of obesity: a brief overview
Genetics of common forms of obesity: a brief overview
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DOI：
10.1093/ajcn/82.1.215s
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发表时间：
2005-07-01
影响因子：
7.1
通讯作者：
Hirschhorn, JN
中科院分区：
文献类型：
--
作者：
Lyon, HN;Hirschhorn, JN
肥胖症的流行可归因于饮食和行为趋势作用于一个人的基因组成，从而决定体重以及对肥胖相关疾病的易感性。常见的肥胖形式具有很强的遗传成分，但导致肥胖的遗传途径尚未阐明。已经报道了许多基因关联研究，但很少能被成功复制。新的研究工具和大规模研究将有助于理解导致肥胖的基因及其相互作用，这可能有助于指导成功的干预措施和治疗。
The obesity epidemic is attributable to dietary and behavioral trends acting on a person's genetic makeup to determine body mass and susceptibility to obesity-related disease. Common forms of obesity have a strong hereditary component, yet genetic pathways that contribute to obesity have not yet been elucidated. Many genetic association studies have been reported, but few have been successfully replicated. New research tools and large studies will lead to an understanding of genes and their interaction to cause obesity, which may help guide successful interventions and treatments.