The cardiovascular effects of nicotine during stress
The cardiovascular effects of nicotine during stress
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DOI：
10.1007/bf00179194
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发表时间：
2004
影响因子：
3.4
通讯作者：
K. A. Perkins;L. H. Epstein;J. Jennings;R. Stiller
中科院分区：
文献类型：
--
作者：
K. A. Perkins;L. H. Epstein;J. Jennings;R. Stiller
在压力期间吸烟对心血管的急性影响可能比吸烟或压力本身更大，这一发现可能对确定哪些吸烟者可能有患冠心病(CHD)的特别风险有意义。使用烟草吸烟传递尼古丁(被认为对吸烟的心血管影响负有责任)所固有的方法问题阻碍了对吸入尼古丁的心血管影响的明确检查。这项研究比较了视频游戏压力任务加1.0毫克尼古丁与压力或单独尼古丁的心血管增加，使用气雾法呈现测量剂量的尼古丁。12名年轻男性吸烟者每人在4个不同的日子里参加了4种情况：压力+尼古丁、压力+安慰剂(单独压力)、休息+尼古丁(单独尼古丁)和休息+安慰剂。压力和尼古丁对心率的影响是相加的，但对收缩压和舒张压的相加作用较小。这些结果表明，压力和尼古丁的联合作用可能与了解吸烟者中CHD的患病率有关。他们还表明，每种药物对心血管活动的影响可能不同，因为它们对心率的影响是独立的，但对血压的影响是重叠的。
The acute cardiovascular effects of smoking during stress may be greater than those of smoking or stress alone, a finding which could have implications for determining which smokers may be at particular risk for coronary heart disease (CHD). Methodological problems inherent in using tobacco smoking to deliver nicotine (believed responsible for smoking's cardiovascular effects) prevent clear examination of the cardiovascular effects of inhaled nicotine. This study compared the cardiovascular increases due to a video game stress task plus 1.0 mg nicotine with those of stress or nicotine alone using an aerosol method of presenting nicotine in measured doses. Twelve young male smokers each participated in four conditions on 4 separate days: stress + nicotine, stress + placebo (stress alone), rest + nicotine (nicotine alone), and rest + placebo. The effects of stress and nicotine were additive for heart rate but less than additive for systolic and diastolic blood pressure. These results indicate that the combined effects of stress and nicotine may be relevant to understanding the prevalence of CHD among smokers. They also suggest that the effects of each on cardiovascular activity may be different, as the effects are independent for heart rate but overlap for blood pressure.